Amanfu Robert K, Saucerman Jeffrey J
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Crit Rev Biomed Eng. 2011;39(5):379-95. doi: 10.1615/critrevbiomedeng.v39.i5.30.
Cardiovascular diseases are among the leading causes of death in the developed world. Developing novel therapies for diseases like heart failure is crucial, but this is hampered by the high attrition rate in drug development. The withdrawal of drugs at the final hurdle of approval is mostly because of their unpredictable effects on normal cardiac rhythm. The advent of cardiac computational modeling in the last 5 decades has aided the understanding of heart function significantly. Recently, these models increasingly have been applied toward designing and understanding therapies for cardiac disease. This article will discuss how cellular models of electrophysiology, cell signaling, and metabolism have been used to investigate pharmacologic therapies for cardiac diseases including arrhythmia, ischemia, and heart failure.
心血管疾病是发达国家主要的死亡原因之一。开发针对心力衰竭等疾病的新型疗法至关重要，但药物研发中的高淘汰率阻碍了这一进程。药物在最终审批阶段被撤回，主要是因为它们对正常心律有不可预测的影响。在过去50年里，心脏计算模型的出现极大地帮助了人们对心脏功能的理解。最近，这些模型越来越多地被用于设计和理解心脏病的治疗方法。本文将讨论电生理学、细胞信号传导和代谢的细胞模型如何被用于研究心律失常、缺血和心力衰竭等心脏病的药物治疗。
