Giancarlo Colombo Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4,500 I-09042 Monserrato (CA), Italy.
Future Oncol. 2014 May;10(7):1203-14. doi: 10.2217/fon.13.276.
This study investigated the protective effect of a standardized extract of Panax ginseng on multiple cisplatin-induced 'sickness behaviors' (model of cancer-induced cachexia) in rats.
MATERIALS & METHODS: Cisplatin was administered twice weekly (1-2 mg/kg, intraperitoneal) for 5 consecutive weeks. Panax ginseng extract (0, 25 and 50 mg/kg, intragastric) was administered daily over the 5-week period of cisplatin exposure. Malaise, bodyweight and temperature, pain sensitivity, and endurance running were recorded at baseline and at 5 weekly intervals.
Treatment with cisplatin produced severe signs of malaise, marked loss of bodyweight, hypothermia, hyperalgesia and reduction in running time. Treatment with Panax ginseng extract completely prevented all cisplatin-induced alterations.
These data indicate that treatment with Panax ginseng extract exerted a protective effect in a rat model of cachexia and suggest that Panax ginseng extract may be a therapeutic promising tool for supportive care in oncology.
本研究旨在探讨人参标准化提取物对顺铂诱导的多种“疾病行为”（癌症相关性恶病质模型）的保护作用。
顺铂每周两次（1-2mg/kg，腹腔内注射）连续 5 周给药。人参提取物（0、25 和 50mg/kg，灌胃）在顺铂暴露的 5 周期间每日给药。在基线和每周 5 次的时间间隔内记录不适、体重和体温、疼痛敏感性和耐力跑步。
顺铂治疗产生严重的不适症状，明显的体重减轻、体温过低、痛觉过敏和跑步时间减少。人参提取物治疗完全预防了所有顺铂诱导的改变。
这些数据表明，人参提取物治疗在恶病质大鼠模型中发挥了保护作用，并表明人参提取物可能是肿瘤支持治疗中很有前途的治疗工具。
