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天然产物在改善癌症相关性恶病质中的作用。

The Role of Natural Products in the Improvement of Cancer-Associated Cachexia.

机构信息

Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Int J Mol Sci. 2023 May 15;24(10):8772. doi: 10.3390/ijms24108772.

Abstract

The enormous library of natural products and herbal medicine prescriptions presents endless research avenues. However, the lack of research evidence and trials on cancer-induced cachexia limit the therapeutic potential of natural products. Cancer-induced cachexia is a systemic wasting syndrome characterized by continuous body weight loss with skeletal muscle and adipose tissue atrophy. Cancer cachexia is a problem in itself and reduces the quality of life by lessening the treatment efficacy of anticancer drugs. This review summarizes single natural product extracts for cancer-induced cachexia, not compounds derived from natural products and herbal medicine prescriptions. This article also discusses the effect of natural products on cachexia induced by anticancer drugs and the role of AMPK in cancer-induced cachexia. The article included the mice model used in each experiment to encourage researchers to utilize animal models for research on cancer-induced cachexia in the future.

摘要

天然产物和草药方剂的巨大宝库为研究提供了无尽的途径。然而,由于缺乏癌症恶病质相关的研究证据和临床试验,限制了天然产物的治疗潜力。癌症恶病质是一种以持续体重减轻伴骨骼肌和脂肪组织萎缩为特征的全身性消耗综合征。癌症恶病质本身就是一个问题,通过降低抗癌药物的治疗效果,降低了生活质量。本综述总结了单一天然产物提取物在癌症恶病质中的应用,而不是来源于天然产物和草药方剂的化合物。本文还讨论了天然产物对癌症恶病质诱导的抗癌药物的影响,以及 AMPK 在癌症恶病质中的作用。本文还包括了每个实验中使用的小鼠模型,以鼓励研究人员在未来利用动物模型研究癌症恶病质。

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