来自中国苔类植物斯蒂芬合叶苔的植物毒性顺式克罗烷二萜类化合物。

Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii.

作者信息

Li Rui-Juan, Sun Yi, Sun Bin, Wang Xiao-Ning, Liu Shan-Shan, Zhou Jin-Chuan, Ye Jian-Ping, Zhao Yu, Liu Lei, Lee Kuo-Hsiung, Lou Hong-Xiang

机构信息

Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan 250012, PR China.

National Glycoengineering Research Center, Shandong University, Jinan 250012, PR China.

出版信息

Phytochemistry. 2014 Sep;105:85-91. doi: 10.1016/j.phytochem.2014.05.019. Epub 2014 Jun 16.

DOI:10.1016/j.phytochem.2014.05.019

PMID:24947338

Abstract

Five cis-clerodane diterpenoids, stephanialides A-E, along with seven known cis-clerodanes, scaparvins A-C, parvitexins B and C, 3-chloro-4-hydroxy-parvitexin A, and scapanialide B, were isolated from the Chinese liverwort Scapania stephanii. Their structures were established unequivocally on the basis of spectroscopic data. The absolute configuration of stephanialide A was determined by analysis of CD data using the octant rule. Phytotoxic activity evaluation showed that this type of diterpenoids can significantly inhibit root elongation of the seeds of Arabidopsis thaliana, Lepidium sativum and Brassica pekinensis.

摘要

从中国产苔类植物斯蒂芬耳叶苔（Scapania stephanii）中分离得到了5个顺式克罗烷二萜类化合物，即斯蒂芬耳叶苔内酯A - E，以及7个已知的顺式克罗烷类化合物，即小耳叶苔素A - C、小叶苔素B和C、3 - 氯 - 4 - 羟基 - 小叶苔素A和耳叶苔内酯B。它们的结构通过光谱数据得以明确确定。斯蒂芬耳叶苔内酯A的绝对构型通过使用八区规则分析圆二色（CD）数据来确定。植物毒性活性评估表明，这类二萜类化合物能够显著抑制拟南芥、独行菜和大白菜种子的根伸长。