Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
J Nat Prod. 2012 Dec 28;75(12):2188-92. doi: 10.1021/np300636k. Epub 2012 Nov 29.
Seven new clerodane diterpenoids (1-7) were isolated from roots of Croton crassifolius, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 1, 3, 4, and 7 were confirmed by single-crystal X-ray diffraction analyses. Compounds 1-13 were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay.
从巴豆根中分离得到了 7 个新的 clerodane 二萜（1-7），以及 6 个已知化合物。通过广泛的光谱方法（IR、UV、HRESIMS、1D NMR 和 2D NMR）阐明了它们的结构，并通过单晶 X 射线衍射分析确定了 1、3、4 和 7 的结构。采用细胞病变效应抑制法评估了化合物 1-13 对单纯疱疹病毒 1 的体外抗病毒活性。
