Maggo Gunjan, Grover Samir C, Grin Andrea
Saba University School of Medicine, Dutch Caribbean, Bonaire, Sint Eustatius and Saba.
Division of Gastroenterology, St. Michael's Hospital, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.
Pathol Res Pract. 2014 Sep;210(9):606-8. doi: 10.1016/j.prp.2014.05.005. Epub 2014 May 22.
Capecitabine is an oral prodrug to 5-fluorouracil and is commonly used in the treatment of advanced breast, colon and stomach cancer. While gastrointestinal toxicity is common, enterocolitis and ischemic colitis are uncommon complications and the histologic features of capecitabine in the colonic mucosa have not been previously described. We present a case of colitis attributed to capecitabine toxicity in a 45-year-old man undergoing treatment of metastatic gastroesophageal adenocarcinoma. Possible pathophysiologic mechanisms of capecitabine toxicity are discussed and the histologic effects on the colon are described.
卡培他滨是一种5-氟尿嘧啶的口服前体药物，常用于治疗晚期乳腺癌、结肠癌和胃癌。虽然胃肠道毒性很常见，但小肠结肠炎和缺血性结肠炎是罕见的并发症，卡培他滨在结肠黏膜中的组织学特征此前尚未见报道。我们报告一例在接受转移性胃食管腺癌治疗的45岁男性中，因卡培他滨毒性导致结肠炎的病例。文中讨论了卡培他滨毒性可能的病理生理机制，并描述了其对结肠的组织学影响。
