Khan Taimoor, Mujtaba Mohamed, Flores Marcus S, Nahum Kenneth, Carson Michael P
Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.
World J Oncol. 2019 Jun;10(3):151-152. doi: 10.14740/wjon1186. Epub 2019 Jun 29.
Ileitis and colitis are known complications of capecitabine when used in patients with gastrointestinal cancers. However, to our knowledge, pneumatosis intestinalis (PI) has not previously been reported with this medication. We present a patient with breast cancer, without any metastases to the gastrointestinal tract, who presented with persistent diarrhea 4 weeks after discontinuing adjuvant capecitabine, which was found to be due to PI. As she had no other risk factors or identifiable causes, her PI was attributed to a delayed reaction to capecitabine. This case highlights the need to consider PI earlier in the differential diagnosis in patients with breast cancer who present with unexplained diarrhea after recent discontinuation of capecitabine.
在胃肠道癌症患者中使用卡培他滨时，回肠炎和结肠炎是已知的并发症。然而，据我们所知，此前尚未有使用该药物导致肠壁积气（PI）的报道。我们报告一例乳腺癌患者，其胃肠道无任何转移，在停用辅助性卡培他滨4周后出现持续性腹泻，经检查发现是由PI所致。由于她没有其他风险因素或可识别的病因，其PI被归因于对卡培他滨的延迟反应。该病例强调，对于近期停用卡培他滨后出现不明原因腹泻的乳腺癌患者，在鉴别诊断时需要更早地考虑PI。
