Temel Tuncer, Meric Ozgenel Safak, Canaz Funda, Arik Deniz, Tokmak Salih, Harmanci Ozakyol Aysegul
Department of Gastroenterology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Department of Pathology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):115-117. doi: 10.5005/jp-journals-10018-1148. Epub 2016 Jul 9.
Although patients with ulcerative colitis have an increased risk for colon cancer which is associated with disease activity, location of involvement or the accompanying primary sclerosing cholangitis, ulcerative colitis induced by resections for colorectal carcinoma or chemotherapy drugs are very rare as case presentations in the literature. Fifty-nine year-old female patient with the diagnosis of sigmoid colon carcinoma have been developed ulcerative colitis 2 months after low anterior resection and oral capecitabine treatment. Development of colitis after colon cancer may be associated with some causes as mutual genetic factors that take part at the pathophysiological mechanisms liable from occurrence of ulcerative colitis and colorectal carcinoma, chemotherapy agents, perioperative stress and underlying silent ulcerative colitis. It is unclear which role is certain. Increasing reports like this case will be useful in resolving this issue.
Temel T, Ozgenel SM, Canaz F, Arik D, Tokmak S, Ozakyol AH. A Case Report of Ulcerative Colitis Induced by Therapy of Colorectal Carcinoma. Euroasian J Hepato-Gastroenterol 2015;5(2):115-117.
尽管溃疡性结肠炎患者患结肠癌的风险增加，且这与疾病活动、受累部位或伴发的原发性硬化性胆管炎有关，但因结直肠癌切除术或化疗药物诱发的溃疡性结肠炎在文献中的病例报道非常罕见。一名59岁诊断为乙状结肠癌的女性患者，在低位前切除术后及口服卡培他滨治疗2个月后发生了溃疡性结肠炎。结肠癌后发生结肠炎可能与多种原因有关，如参与溃疡性结肠炎和结直肠癌发病病理生理机制的共同遗传因素、化疗药物、围手术期应激以及潜在的隐匿性溃疡性结肠炎。尚不清楚哪种因素起决定性作用。像这样的病例报告不断增加将有助于解决这一问题。
Temel T, Ozgenel SM, Canaz F, Arik D, Tokmak S, Ozakyol AH. 一例结直肠癌治疗诱发溃疡性结肠炎的病例报告。《欧亚肝脏胃肠病学杂志》2015年；5(2):115 - 117。
