结肠癌中OTUB1呈过表达。
Colon cancer bears overexpression of OTUB1.
作者信息
Liu Xin, Jiang Wei-Na, Wang Ji-Gang, Chen Hua
机构信息
Department of Pathology, Qingdao University Medical College, China.
Department of Pathology, Qingdao Municipal Hospital, China.
出版信息
Pathol Res Pract. 2014 Nov;210(11):770-3. doi: 10.1016/j.prp.2014.05.008. Epub 2014 May 22.
OBJECTIVE
OTUB1 is a member of deubiquitinating enzymes; however, its expression and function in colon cancer are still unclear. The present study aimed at investigating the expression of OTUB1 in colon cancer and the relationship between the expression and some clinicopathologic parameters.
METHODS
Immunohistochemistry and quantitative real-time PCR were carried out in selected colon cancer and normal mucosa tissues.
RESULTS
The expression of OTUB1 protein in the colon cancer was significantly higher than normal mucosa, and the OTUB1 mRNA in colon cancer was also 3.15-fold higher than the normal mucosa. The higher expression of OTUB1 in colon cancer was related with tumor size, differentiation and lymph node metastasis.
CONCLUSIONS
OTUB1 may play an important role in colon cancer development and metastasis.
目的
OTUB1是去泛素化酶家族成员之一；然而，其在结肠癌中的表达及功能仍不清楚。本研究旨在探讨OTUB1在结肠癌中的表达情况及其与某些临床病理参数之间的关系。
方法
对选取的结肠癌组织和正常黏膜组织进行免疫组织化学和定量实时聚合酶链反应检测。
结果
结肠癌组织中OTUB1蛋白表达明显高于正常黏膜组织，且结肠癌组织中OTUB1信使核糖核酸水平也比正常黏膜组织高3.15倍。OTUB1在结肠癌中的高表达与肿瘤大小、分化程度及淋巴结转移有关。
结论
OTUB1可能在结肠癌的发生发展及转移过程中发挥重要作用。
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