• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

非编码 RNA OTUB1-isoform2 促进卵巢肿瘤进展并预测不良预后。

The non-coding RNA OTUB1-isoform2 promotes ovarian tumour progression and predicts poor prognosis.

机构信息

Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.

出版信息

J Cell Mol Med. 2018 Oct;22(10):4794-4806. doi: 10.1111/jcmm.13733. Epub 2018 Jul 25.

DOI:10.1111/jcmm.13733
PMID:30044532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6156285/
Abstract

Ovarian cancer is the leading malignancy of the female reproductive system and is associated with inconspicuous early invasion and metastasis. We have previously reported that the oncogene OTUB1 plays a crucial role in ovarian cancer progression, but the role of its isoform, the non-coding RNA OTUB1-isoform2, in ovarian cancer is still elusive. Here, we reported that OTUB1-isoform2 expression in ovarian cancer tissues was significantly higher than that in the paired paratumorous tissues (P < .01). The patients with high expression of OTUB1-isoform2 had larger tumours than those with low expression (P < .05). The high expression of OTUB1-isoform2 was correlated with the involvement of bilateral ovaries (P < .05), lymph node metastasis (P < .05), vascular invasion (P < .05), greater omentum involvement (P < .01), fallopian tube involvement (P < .05), advanced FIGO stages (P < .01) and recurrence (P < .01). Moreover, OTUB1-isoform2 served as an independent negative prognostic predictor for disease-free survival (DFS) and disease-specific survival (DSS). Overexpression of OTUB1-isoform2 in the ovarian cancer cells stimulated cell proliferation, migration and invasion both in vitro and in vivo. In summary, our study suggested that OTUB1-isoform2 is a novel prognostic biomarker with independent oncogenic functions for ovarian cancer.

摘要

卵巢癌是女性生殖系统中最常见的恶性肿瘤，其早期侵袭和转移不明显。我们之前报道过癌基因 OTUB1 在卵巢癌进展中起着关键作用，但它的异构体，非编码 RNA OTUB1-isoform2，在卵巢癌中的作用仍不清楚。在这里，我们报道了卵巢癌组织中 OTUB1-isoform2 的表达明显高于配对的癌旁组织（P<0.01）。OTUB1-isoform2 高表达的患者肿瘤比低表达的患者大（P<0.05）。OTUB1-isoform2 的高表达与双侧卵巢受累（P<0.05）、淋巴结转移（P<0.05）、血管浸润（P<0.05）、大网膜受累（P<0.01）、输卵管受累（P<0.05）、FIGO 分期较高（P<0.01）和复发（P<0.01）有关。此外，OTUB1-isoform2 是无病生存（DFS）和疾病特异性生存（DSS）的独立预后不良预测因子。OTUB1-isoform2 在卵巢癌细胞中的过表达在体外和体内均刺激细胞增殖、迁移和侵袭。综上所述，我们的研究表明，OTUB1-isoform2 是一种具有独立致癌功能的新型卵巢癌预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/310e738ad0b1/JCMM-22-4794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/9f2fc2115f51/JCMM-22-4794-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/15d165fb682b/JCMM-22-4794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/68e0966b2d22/JCMM-22-4794-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/715a48f817e0/JCMM-22-4794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/e557baef405f/JCMM-22-4794-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/310e738ad0b1/JCMM-22-4794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/9f2fc2115f51/JCMM-22-4794-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/15d165fb682b/JCMM-22-4794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/68e0966b2d22/JCMM-22-4794-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/715a48f817e0/JCMM-22-4794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/e557baef405f/JCMM-22-4794-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5426/6156285/310e738ad0b1/JCMM-22-4794-g006.jpg

相似文献

1
The non-coding RNA OTUB1-isoform2 promotes ovarian tumour progression and predicts poor prognosis.非编码 RNA OTUB1-isoform2 促进卵巢肿瘤进展并预测不良预后。
J Cell Mol Med. 2018 Oct;22(10):4794-4806. doi: 10.1111/jcmm.13733. Epub 2018 Jul 25.
2
Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis.非编码RNA OTUB1-亚型2的上调促进胃癌细胞增殖和侵袭并预示胃癌预后不良。
Int J Biol Sci. 2016 Mar 3;12(5):545-57. doi: 10.7150/ijbs.13540. eCollection 2016.
3
Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer.长链非编码RNA LOC400891的过表达促进前列腺癌的肿瘤进展和不良预后。
Tumour Biol. 2016 Jul;37(7):9603-13. doi: 10.1007/s13277-016-4847-y. Epub 2016 Jan 21.
4
Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion.OTUB1在肝细胞癌中的表达及其对肝癌细胞迁移和侵袭的影响。
Acta Biochim Biophys Sin (Shanghai). 2017 Aug 1;49(8):680-688. doi: 10.1093/abbs/gmx056.
5
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.OTUB1促进结直肠癌转移并作为其预后不良的标志物。
Mol Cancer. 2014 Nov 28;13:258. doi: 10.1186/1476-4598-13-258.
6
Up-regulation of long intergenic noncoding RNA 01296 in ovarian cancer impacts invasion, apoptosis and cell cycle distribution via regulating EMT.长链非编码 RNA 01296 在卵巢癌中的上调通过调节 EMT 影响侵袭、凋亡和细胞周期分布。
Cell Signal. 2019 Oct;62:109341. doi: 10.1016/j.cellsig.2019.06.006. Epub 2019 Jun 5.
7
SALL4 is a marker of poor prognosis in serous ovarian carcinoma promoting invasion and metastasis.SALL4是浆液性卵巢癌预后不良的一个标志物，可促进侵袭和转移。
Oncol Rep. 2016 Mar;35(3):1796-806. doi: 10.3892/or.2016.4545. Epub 2016 Jan 5.
8
Upregulation of SNHG3 expression associated with poor prognosis and enhances malignant progression of ovarian cancer.SNHG3 表达上调与卵巢癌预后不良相关，并增强其恶性进展。
Cancer Biomark. 2018;22(3):367-374. doi: 10.3233/CBM-170710.
9
Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis.长非编码 RNA NRON 在 HCC 中下调，抑制肿瘤细胞增殖和转移。
Biomed Pharmacother. 2018 Aug;104:102-109. doi: 10.1016/j.biopha.2018.05.006. Epub 2018 May 15.
10
The long non-coding RNA CCAT2 is up-regulated in ovarian cancer and associated with poor prognosis.长链非编码RNA CCAT2在卵巢癌中上调，并与不良预后相关。
Diagn Pathol. 2016 Jun 10;11(1):49. doi: 10.1186/s13000-016-0499-x.

引用本文的文献

1
OTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death.OTUB1/NDUFS2轴通过防止线粒体细胞死亡促进胰腺肿瘤发生。
Cell Death Discov. 2024 Apr 23;10(1):190. doi: 10.1038/s41420-024-01948-x.
2
The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization.去泛素化酶 OTUB1 通过稳定 EYA1 促进甲状腺乳头癌生长。
J Cell Mol Med. 2021 Dec;25(23):10980-10989. doi: 10.1111/jcmm.17020. Epub 2021 Nov 12.
3
Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer.

本文引用的文献

1
LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer.长链非编码 RNA HOTTIP 介导的 HOXA11 表达促进乳腺癌细胞的生长、迁移并抑制细胞凋亡。
Int J Mol Sci. 2018 Feb 6;19(2):472. doi: 10.3390/ijms19020472.
2
Health-related quality of life and pelvic floor dysfunction in advanced-stage ovarian cancer survivors: associations with objective activity behaviors and physiological characteristics.晚期卵巢癌幸存者的健康相关生活质量与盆底功能障碍：与客观活动行为和生理特征的关联。
Support Care Cancer. 2018 Jul;26(7):2239-2246. doi: 10.1007/s00520-018-4069-5. Epub 2018 Feb 1.
3
卵巢癌预后因素及生物标志物的研究进展
J Cancer. 2021 May 13;12(13):3976-3996. doi: 10.7150/jca.47695. eCollection 2021.
Survival prediction of kidney renal papillary cell carcinoma by comprehensive LncRNA characterization.
通过全面的长链非编码RNA特征对肾肾乳头状细胞癌进行生存预测
Oncotarget. 2017 Nov 28;8(67):110811-110829. doi: 10.18632/oncotarget.22732. eCollection 2017 Dec 19.
4
Cancer Statistics, 2017.《2017 年癌症统计》
CA Cancer J Clin. 2017 Jan;67(1):7-30. doi: 10.3322/caac.21387. Epub 2017 Jan 5.
5
lncRNAs as Novel Indicators of Patients' Prognosis in Stage I Epithelial Ovarian Cancer: A Retrospective and Multicentric Study.lncRNAs 作为Ⅰ期上皮性卵巢癌患者预后的新型标志物：一项回顾性多中心研究。
Clin Cancer Res. 2017 May 1;23(9):2356-2366. doi: 10.1158/1078-0432.CCR-16-1402. Epub 2016 Nov 8.
6
A Positive Feedback Loop of lncRNA- and FOXM1 Facilitates Gastric Cancer Growth and Invasion.lncRNA 和 FOXM1 的正反馈环促进胃癌的生长和侵袭。
Clin Cancer Res. 2017 Apr 15;23(8):2071-2080. doi: 10.1158/1078-0432.CCR-16-0742. Epub 2016 Oct 18.
7
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.OTUB1促进胃腺癌的肿瘤侵袭并预示不良预后。
Am J Transl Res. 2016 May 15;8(5):2234-44. eCollection 2016.
8
FIGO stage IV epithelial ovarian, fallopian tube and peritoneal cancer revisited.FIGO 分期 IV 期卵巢上皮癌、输卵管癌和腹膜癌再评估。
Gynecol Oncol. 2016 Sep;142(3):597-607. doi: 10.1016/j.ygyno.2016.06.013. Epub 2016 Jun 19.
9
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.OTUB1催化的FOXM1去泛素化促进肿瘤进展并预示卵巢癌预后不良。
Oncotarget. 2016 Jun 14;7(24):36681-36697. doi: 10.18632/oncotarget.9160.
10
Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis.非编码RNA OTUB1-亚型2的上调促进胃癌细胞增殖和侵袭并预示胃癌预后不良。
Int J Biol Sci. 2016 Mar 3;12(5):545-57. doi: 10.7150/ijbs.13540. eCollection 2016.