Aubin A, Pondaven S, Bakhos D, Lardy H, Robier A, Lescanne E
Service ORL, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnelé, 37044 Tours cedex 9, France.
Service ORL, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnelé, 37044 Tours cedex 9, France.
Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Nov;131(5):271-5. doi: 10.1016/j.anorl.2012.05.006. Epub 2014 Jun 16.
Congenital teratomas of the oropharyngeal cavity are extremely rare and are associated with a high neonatal mortality rate due to severe airway obstruction. Management has been improved with progress in antenatal diagnosis. The authors describe this progress in the light of a series of 4 cases and a review of the literature.
The medical charts of four neonates treated in the department since 1995 were reviewed. The following criteria were studied: age at diagnosis, clinical and radiological features of the tumour, management at birth and outcome.
All four cases occurred in female neonates with an antenatal diagnosis in two cases, allowing preparation for endoscopy in the delivery room in one case and an EXIT procedure in the other case. Three neonates had to be intubated in the delivery room. Imaging showed invasion of the infratemporal fossa in 3 of the 4 cases. Surgical resection via various approaches to the infratemporal fossa was complete in every case. Adjuvant chemotherapy was administered in one case.
Surgery for these mostly benign tumours is very challenging and requires a multidisciplinary team. Perinatal planning allows appropriate management at birth, decreasing the risk of airway obstruction. Surgery is the mainstay of treatment of teratomas.
口咽腔先天性畸胎瘤极为罕见，因严重气道阻塞导致新生儿死亡率很高。随着产前诊断技术的进步，其治疗方法有所改进。作者根据4例病例及文献复习描述了这一进展。
回顾了自1995年以来在该科室接受治疗的4例新生儿的病历。研究了以下标准：诊断时的年龄、肿瘤的临床和放射学特征、出生时的治疗及结局。
所有4例均发生于女性新生儿，其中2例产前诊断，1例因此在产房准备了内镜检查，另1例准备了EXIT手术。3例新生儿在产房需行气管插管。影像学检查显示4例中有3例侵犯颞下窝。每例均通过多种入路对颞下窝进行了完整的手术切除。1例接受了辅助化疗。
这些大多为良性肿瘤的手术极具挑战性，需要多学科团队协作。围产期规划可使出生时得到恰当治疗，降低气道阻塞风险。手术是畸胎瘤治疗的主要手段。
