Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Chem Soc Rev. 2014;43(20):6982-7012. doi: 10.1039/c4cs00133h. Epub 2014 Jun 19.
This review provides an overview of smart chemistry developed and utilized in the last 5-10 years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the controlled drug loading in a highly specific manner, but also potentially controls the drug release kinetics at the targeted tissues. This review highlights the emergence of new chemistry or unique utilization of conventional chemistry in drug delivery, which is believed to play an important role in developing next generation nanomedicine.
本篇综述介绍了过去 5-10 年在基于聚合物的药物传递纳米医学中开发和利用的智能化学。智能化学不仅可以以高度特异的方式促进药物的控制加载，还可以潜在地控制靶向组织中的药物释放动力学。本综述强调了在药物传递中出现的新化学或常规化学的独特利用，这被认为在开发下一代纳米医学中发挥着重要作用。
