Department of Chemistry, Faculty of Science and Technology, Lancaster University, Bailrigg, Lancaster LA1 4YB, U.K.
Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, U.K.
Biomacromolecules. 2022 Jul 11;23(7):3031-3040. doi: 10.1021/acs.biomac.2c00516. Epub 2022 Jun 24.
Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10-30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.
在农业科学/医疗保健行业，能够精确控制农用化学品/生物制剂/药物/香料递送的生物材料具有巨大的市场。在这里，我们报告了可降解的电活性聚合物的开发及其在临床相关药物（抗炎药磷酸地塞米松，DMP）的控制释放中的应用。由聚己内酯（PCL）和天然存在的电活性吡咯低聚物（例如胆红素、胆绿素和血红素）组成的电活性嵌段共聚物被制备并进行溶液处理以生产薄膜（可选地掺杂有 DMP）。计算机模拟/体外/体内研究的组合表明了聚合物的细胞相容性。体外观察到，与非刺激样品的被动释放相比，响应电刺激的 DMP 的释放增强了约 10-30%。这种对刺激有响应的生物材料有可能集成能够递送各种分子的设备，用于技术/医疗应用。
