Posalaky Z, Posalaky I, McGinley D, Meyer R A
Department of Pathology, St. Paul-Ramsey Medical Center, Minnesota 55101.
Virchows Arch A Pathol Anat Histopathol. 1989;414(3):217-22. doi: 10.1007/BF00822025.
Tight junctions of the human gastric mucosa were examined using quantitative freeze-fracture methods. Biopsies examined were from patients with gastric diseases including gastritis, ulcers, and pernicious anemia. No significant differences were seen in strand number or tight junction complex depth among the biopsies analyzed, however, anomalous tight junction structures were observed. Discontinuities in the tight junctions complex and hyperplastic tight junctions (extensions of the apical tight junction strands radiating over the lateral plasma membrane) were seen. These alterations were not associated exclusively with either the diagnosis of gastritis or ulcers. However, a higher frequency of tight junction breaks was seen in stomach biopsies diagnosed as gastritis while those diagnosed as ulcers displayed a higher occurrence of hyperplastic tight junctions.
采用定量冷冻断裂方法对人胃黏膜的紧密连接进行了检查。所检查的活检样本来自患有胃炎、溃疡和恶性贫血等胃部疾病的患者。在所分析的活检样本中，紧密连接链的数量或紧密连接复合体深度未见显著差异，然而，观察到了异常的紧密连接结构。可见紧密连接复合体的不连续性和增生性紧密连接（顶端紧密连接链延伸至外侧质膜）。这些改变并非仅与胃炎或溃疡的诊断相关。然而，诊断为胃炎的胃活检样本中紧密连接断裂的频率较高，而诊断为溃疡的样本中增生性紧密连接的发生率较高。
