Meyer R A, McGinley D, Posalaky Z
J Ultrastruct Res. 1984 Feb;86(2):192-201. doi: 10.1016/s0022-5320(84)80058-1.
The canine gastric mucosa consists of two regions, the surface mucous cells and gland area cells including parietal, chief, and mucous-containing cells. We have used quantitative freeze-fracture methods in conjunction with thin-section extracellular tracers to document and correlate tight junction morphology with epithelial permeability. The number of strands in the tight junction complexes of the surface cells and gland cells is the same, but differences in strand arrangement exist. The surface cells have an interwoven tight junction configuration which is impermeable to extracellular tracers. The gland cell junctions are regularly arranged and often permeable to extracellular lanthanum. The possibility that the observed difference in permeability between the tight junctions of the surface mucous cells and those of the gland cells is related to their structural configuration is discussed.
犬胃黏膜由两个区域组成，即表面黏液细胞和腺区细胞，后者包括壁细胞、主细胞和含黏液细胞。我们使用定量冷冻断裂方法并结合薄切片细胞外示踪剂，来记录紧密连接形态并将其与上皮通透性相关联。表面细胞和腺细胞紧密连接复合体中的嵴线数量相同，但嵴线排列存在差异。表面细胞具有交织的紧密连接结构，对细胞外示踪剂不可渗透。腺细胞连接排列规则，通常对细胞外镧可渗透。本文讨论了表面黏液细胞和腺细胞紧密连接之间观察到的通透性差异可能与其结构构型有关的可能性。
