Okajima K, Koga S, Okabe H, Inoue M, Takatsuki K
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
Acta Haematol. 1989;81(1):15-8. doi: 10.1159/000205392.
Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when alpha 2-plasmin inhibitor (alpha 2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients when the alpha 2-PI level has decreased significantly.
与急性早幼粒细胞白血病（APL）相关的弥散性血管内凝血（DIC）患者的血浆样本，相较于非APL的DIC样本，显示出更高水平的纤维蛋白和纤维蛋白原降解产物的D片段[FDP(D)]，而交联纤维蛋白降解产物（XDP）水平相对较低。仅当APL患者的α2 - 纤溶酶抑制剂（α2 - PI）降至正常水平的60%以下时，FDP(D)和XDP水平之间的差异才会增大。这些发现表明，当α2 - PI水平显著降低时，APL患者会发生纤维蛋白原溶解。
