髌软骨中的糖胺聚糖
Glycosaminoglycans in patellar cartilage.
作者信息
Olsen E B, Trier K, Møller H
机构信息
Department of Dermatology, Rigshospital, University of Copenhagen, Denmark.
出版信息
Acta Orthop Scand. 1989 Feb;60(1):23-5. doi: 10.3109/17453678909150084.
We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetate electrophoresis, and the relative content of major glycosaminoglycans was measured by optic scanning. The total content of glycosaminoglycans was estimated by uronic acid analysis. We found that degenerated cartilage contained an increase in dermatan sulfate and hyaluronic acid and a decrease in chondroitin 6-sulfate and total uronic acid concentration, with only slight changes in chondroitin 4-sulfate and keratan sulfate compared with normal cartilage.
我们在手术时从20名患者身上获取了髌软骨样本：其中11名患者的髌软骨正常，9名患者的髌软骨有肉眼可见的退变。通过醋酸纤维素电泳分离糖胺聚糖，并通过光学扫描测量主要糖胺聚糖的相对含量。通过糖醛酸分析估算糖胺聚糖的总含量。我们发现，与正常软骨相比，退变软骨中的硫酸皮肤素和透明质酸含量增加，硫酸软骨素6 - 硫酸酯和总糖醛酸浓度降低，而硫酸软骨素4 - 硫酸酯和硫酸角质素仅有轻微变化。
Zotero 插件