Stenfors L E, Räisänen S
Department of Otolaryngology, Central Hospital of Keski-Pohjanmaa, Kokkola, Finland.
Acta Otolaryngol. 1989 Mar-Apr;107(3-4):244-8. doi: 10.3109/00016488909127504.
Middle ear pathogens (S. pneumoniae, H. influenzae, B. catarrhalis, S. aureus and coagulase-negative staphylococci) were injected into 28 samples of mucoid effusion materials taken from 17 patients suffering from secretory otitis media. In every case the effusion material was sticky, hydrophilic and thick and contained no bacteria. S. pneumoniae and H. influenzae survived for only 1-2 days in mucoid effusion material incubated at 37 degrees C, while B. catarrhalis and staphylococci survived for at least 18-36 days when incubated in this medium. It seems that mucoid effusion material filling the middle ear cavity during secretory otitis media has a dual function in providing protection against middle ear infections. Thanks to its physical properties the effusion material hinders bacteria from ascending from the nasopharynx and is a poor substrate for some microorganisms. In contrast, mucoid effusion material is a superior medium for B. catarrhalis and staphylococci.
将中耳病原体（肺炎链球菌、流感嗜血杆菌、卡他莫拉菌、金黄色葡萄球菌和凝固酶阴性葡萄球菌）注入取自17例分泌性中耳炎患者的28份黏液样积液样本中。在每种情况下，积液材料都黏稠、亲水且浓稠，并且不含细菌。肺炎链球菌和流感嗜血杆菌在37℃孵育的黏液样积液材料中仅存活1 - 2天，而卡他莫拉菌和葡萄球菌在此培养基中孵育时至少存活18 - 36天。似乎在分泌性中耳炎期间填充中耳腔的黏液样积液材料在预防中耳感染方面具有双重作用。由于其物理特性，积液材料阻碍细菌从鼻咽部上升，并且对某些微生物而言是不良培养基。相比之下，黏液样积液材料是卡他莫拉菌和葡萄球菌的优质培养基。
