Gagliani Nicola, Palm Noah W, de Zoete Marcel R, Flavell Richard A
Department of Immunobiology, School of Medicine, Yale University, The Anlyan Center, 300 Cedar Street S560, S570 New Haven, CT 06519, USA.
Department of Immunobiology, School of Medicine, Yale University, The Anlyan Center, 300 Cedar Street S560, S570 New Haven, CT 06519, USA Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Int Immunol. 2014 Sep;26(9):495-9. doi: 10.1093/intimm/dxu066. Epub 2014 Jun 19.
Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.
炎性小体是大型胞质蛋白复合物，可检测感染和应激相关信号并促进即时炎症反应。在肠道中，炎性小体的激活会引发炎症反应，这对于控制肠道感染很重要，但也可能导致病理性组织损伤。最近的研究表明，炎性小体还通过其对肠道微生物群的影响来调节肠道稳态。值得注意的是，关于炎性小体缺陷对肠道稳态的影响，已经发表了许多相互矛盾的研究。在这里，我们试图通过强调炎性小体促进肠道稳态和病理的多种方式，并探讨微生物群改变在这些相互矛盾的研究中的潜在作用，来调和这些相互矛盾的数据。
