让我们开始这个（炎症）蛋白吧！
Let's get this pyrin started!
机构信息
From the Microbiome and Mucosal Defense Research Unit, Montreal Clinical Research Institute (IRCM), Montréal, Quebec H2W 1R7, Canada,
Department of Medicine, Université de Montréal, Montréal, Quebec H3C 3J7, Canada, and.
出版信息
J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830.
Abstract
Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest that microbiota may be able to modulate this inflammatory process which, in turn, may contribute to the maintenance of intestinal homeostasis.
摘要
炎症小体使细胞能够对病原体或生物损伤做出反应，但用于传递这些信息的特定信号并不总是清楚的。一篇新论文确定了两种潜在的微生物衍生代谢物，胆汁酸类似物 BAA485 和 BAA473，作为第一个激活吡喃炎症小体的小分子。这些结果表明，微生物群可能能够调节这种炎症过程，反过来，这可能有助于维持肠道内稳态。
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本文引用的文献
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Bile acid analogues are activators of pyrin inflammasome.胆汁酸类似物是 pyrin 炎症小体的激活剂。
J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15.
2
Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.吡啉炎性小体调节紧密连接完整性以限制结肠炎和肿瘤发生。
Gastroenterology. 2018 Mar;154(4):948-964.e8. doi: 10.1053/j.gastro.2017.11.276. Epub 2017 Dec 2.
3
Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.炎症小体在先天免疫识别和代谢控制的十字路口。
Cell Metab. 2017 Jul 5;26(1):71-93. doi: 10.1016/j.cmet.2017.06.018.
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Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.家族性地中海热突变解除了微管蛋白在吡啉炎性小体激活中的必要需求。
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14384-14389. doi: 10.1073/pnas.1613156113. Epub 2016 Nov 22.
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Inflammasomes: mechanism of assembly, regulation and signalling.炎症小体：组装、调控和信号转导机制。
Nat Rev Immunol. 2016 Jul;16(7):407-20. doi: 10.1038/nri.2016.58. Epub 2016 Jun 13.
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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.微生物群调节的代谢产物通过调节NLRP6炎性小体信号塑造肠道微环境。
Cell. 2015 Dec 3;163(6):1428-43. doi: 10.1016/j.cell.2015.10.048.
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Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.代谢物感应受体 GPR43 和 GPR109A 通过调节炎症小体促进膳食纤维诱导的肠道稳态。
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