From the Microbiome and Mucosal Defense Research Unit, Montreal Clinical Research Institute (IRCM), Montréal, Quebec H2W 1R7, Canada,
Department of Medicine, Université de Montréal, Montréal, Quebec H3C 3J7, Canada, and.
J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830.
Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest that microbiota may be able to modulate this inflammatory process which, in turn, may contribute to the maintenance of intestinal homeostasis.
炎症小体使细胞能够对病原体或生物损伤做出反应，但用于传递这些信息的特定信号并不总是清楚的。一篇新论文确定了两种潜在的微生物衍生代谢物，胆汁酸类似物 BAA485 和 BAA473，作为第一个激活吡喃炎症小体的小分子。这些结果表明，微生物群可能能够调节这种炎症过程，反过来，这可能有助于维持肠道内稳态。
