老年和青年乳腺癌的临床病理及其预后。
Clinical pathologies of breast cancer in the elderly and youths and their prognosis.
机构信息
Hong Ji, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
Ning Ai, Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
出版信息
Pak J Med Sci. 2014 May;30(3):535-8. doi: 10.12669/pjms.303.4929.
OBJECTIVE
To explore the correlation between the clinical pathologies of breast cancer in the elderly and youths as well as their prognosis.
METHODS
Two hundred and eighty breast cancer patients were divided into a youth group (<60, n=120) and an elderly group (≥60, n=160) according to the age. Their routine clinical pathological indices and immune indices were observed and determined, and the prognosis was observed after effective treatment.
RESULTS
The positive expression rates of p63, CK5/6, CK14 and CK17 in the elderly group were significantly higher than those of the youth group (P<0.05). The tumor-free survival rate of the youth group (95.8%) was significantly higher than that of the elderly group (84.4%) (P<0.05). Multivariate Logistic regression analysis showed that the positive expressions of p63 and estrogen receptor, age, and postoperative chemotherapy were the independent risk factors of tumor-free survival rate (P<0.05).
CONCLUSION
The immunohistochemical typing characteristics of the elderly and youths were different, and the prognosis of young patients was better, being correlated with the typing.
目的
探讨老年和青年乳腺癌的临床病理特征及其与预后的关系。
方法
将 280 例乳腺癌患者按年龄分为青年组(<60 岁，n=120)和老年组(≥60 岁，n=160)。观察并确定其常规临床病理指标和免疫指标，并在有效治疗后观察其预后。
结果
老年组 p63、CK5/6、CK14 和 CK17 的阳性表达率明显高于青年组(P<0.05)。青年组无瘤生存率(95.8%)明显高于老年组(84.4%)(P<0.05)。多因素 Logistic 回归分析显示，p63 和雌激素受体阳性、年龄和术后化疗是无瘤生存率的独立危险因素(P<0.05)。
结论
老年和青年患者的免疫组织化学分型特征不同，青年患者的预后较好，与分型有关。
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