Oyeyemi Bolaji Fatai, Iyiola Oluyinka Ajibola, Oyeyemi Adekunle Wahab, Oricha Kokori Audu, Anifowoshe Abass Toba, Alamukii Nanfizat Abiket
Department of Zoology, Cell Biology and Genetics Unit, University of Ibadan, Ibadan, Oyo State, Nigeria.
Department of Zoology, University of Ilorin, P.M.B. 1515, Ilorin, Kwara State, Nigeria ; Department of Molecular Biology & Biotechnology, University of Sheffield, Firth Court, S10 2TN Sheffield, United Kingdom.
J Res Med Sci. 2014 Mar;19(3):234-9.
Ratio of second and fourth digit (2D:4D) is known to be germane in analyzing utero concentrations of testosterone and estrogen in human and other vertebrates. 2D:4D had been linked to several traits like athletes' abilities, reproductive success, risk of cancer and cardiovascular disease (CVD). Metabolic syndrome (MetS) is a clustering of several cardiovascular risk factors. Waist circumference (WC), neck circumference (NC), body mass index (BMI) and waist-to-height ratio (WHtR) are important in measuring MetS. This study investigated sexual dimorphism in 2D:4D and its relationship with MetS indices and CVD factors among adult residing in Ilorin, North central Nigeria.
This is a cross-sectional, stratified multi-staged sampling study. Participants residing in different neighborhoods were visited at home where finger lengths and anthropometric traits were measured. Participants include 801 healthy adults aged 18-44 years (56% male) who had been living in the area for more than 3 years.
Males showed significantly lower 2D:4D than females (unpaired t-test; t [699] = 11.49, P = 0.001). A significant positive correlation was observed in MetS markers and 2D:4D. WHtR showed the highest correlation with 2D:4D in male (r = 0.461, P ≤ 0.001) and female (r = 0.408, P ≤ 0.001) when compared with BMI, NC and WC. All positive correlations recorded in this study were high in male and right hand.
Our results showed that 2D:4D is sexual dimorphic and right hand 2D:4D as a predictor of MetS is better. We concluded that 2D:4D is a proxy for MetS and CVD risk factors in Ilorin.
已知第二和第四指长度之比（2D:4D）在分析人类和其他脊椎动物子宫内睾酮和雌激素浓度方面具有相关性。2D:4D与多种特征相关，如运动员能力、生殖成功率、癌症风险和心血管疾病（CVD）。代谢综合征（MetS）是几种心血管危险因素的聚集。腰围（WC）、颈围（NC）、体重指数（BMI）和腰高比（WHtR）在衡量MetS方面很重要。本研究调查了尼日利亚中北部伊洛林成年居民中2D:4D的性别差异及其与MetS指标和CVD因素的关系。
这是一项横断面、分层多阶段抽样研究。研究人员到居住在不同社区的参与者家中，测量其手指长度和人体测量特征。参与者包括801名年龄在18 - 44岁的健康成年人（56%为男性），他们在该地区居住超过3年。
男性的2D:4D显著低于女性（未配对t检验；t[699]=11.49，P = 0.001）。在MetS标志物和2D:4D之间观察到显著的正相关。与BMI、NC和WC相比，WHtR在男性（r = 0.461，P≤0.001）和女性（r = 0.408，P≤0.001）中与2D:4D的相关性最高。本研究记录的所有正相关在男性和右手方面都很高。
我们的结果表明，2D:4D存在性别差异，右手2D:4D作为MetS的预测指标更好。我们得出结论，在伊洛林，2D:4D可作为MetS和CVD危险因素的替代指标。
