Zhong Lei, Zhu Kuixi, Jin Nana, Wu Deng, Zhang Jianguo, Guo Baoliang, Yan Zhaoqi, Zhang Qingyuan
Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Department of Bioinformatics, Harbin Medical University, Harbin 150081, China.
Biomed Res Int. 2014;2014:291280. doi: 10.1155/2014/291280. Epub 2014 May 18.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate gene expression by binding to target mRNAs and induce translation repression or RNA degradation. There have been many studies indicating that both miRNAs and mRNAs display aberrant expression in breast cancer. Previously, most researches into the molecular mechanism of breast cancer examined miRNA expression patterns and mRNA expression patterns separately. In this study, we systematically analysed miRNA-mRNA paired variations (MMPVs), which are miRNA-mRNA pairs whose pattern of regulation can vary in association with biopathological features, such as the oestrogen receptor (ER), TP53 and human epidermal growth factor receptor 2 (HER2) genes, survival time, and breast cancer subtypes. We demonstrated that the existence of MMPVs is general and widespread but that there is a general unbalance in the distribution of MMPVs among the different biopathological features. Furthermore, based on studying MMPVs that are related to multiple biopathological features, we propose a potential crosstalk mechanism between ER and HER2.
微小RNA（miRNA）是一类小的非编码RNA，其可通过与靶mRNA结合来调节基因表达，并诱导翻译抑制或RNA降解。已有许多研究表明，miRNA和mRNA在乳腺癌中均表现出异常表达。此前，大多数关于乳腺癌分子机制的研究分别检测了miRNA表达模式和mRNA表达模式。在本研究中，我们系统地分析了微小RNA-信使核糖核酸配对变异（MMPV），即其调控模式可随生物病理学特征（如雌激素受体（ER）、TP53和人表皮生长因子受体2（HER2）基因、生存时间和乳腺癌亚型）而变化的微小RNA-信使核糖核酸对。我们证明，MMPV的存在是普遍且广泛的，但不同生物病理学特征之间MMPV的分布普遍不均衡。此外，基于对与多种生物病理学特征相关的MMPV的研究，我们提出了一种ER与HER2之间潜在的相互作用机制。
