Kurita-Ochiai Tomoko, Yamamoto Masafumi
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan.
Biomed Res Int. 2014;2014:595981. doi: 10.1155/2014/595981. Epub 2014 May 18.
Inflammation is well accepted to play a crucial role in the development of atherosclerotic lesions, and recent studies have demonstrated an association between periodontal disease and cardiovascular disease. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, causative agents of destructive chronic inflammation in the periodontium, can accelerate atheroma deposition in animal models. Emerging evidence suggests that vaccination against virulence factors of these pathogens and anti-inflammatory therapy may confer disease resistance. In this review, we focus on the role of inflammatory mechanisms and oxidative modification in the formation and activation of atherosclerotic plaques accelerated by P. gingivalis or A. actinomycetemcomitans in an ApoE-deficient mouse model and high-fat-diet-fed mice. Furthermore, we examine whether mucosal vaccination with a periodontal pathogen or the anti-inflammatory activity of catechins can reduce periodontal pathogen-accelerated atherosclerosis.
炎症在动脉粥样硬化病变的发展中起着关键作用，这一点已被广泛接受，并且最近的研究表明牙周疾病与心血管疾病之间存在关联。牙龈卟啉单胞菌和伴放线聚集杆菌是牙周组织中破坏性慢性炎症的病原体，它们可在动物模型中加速动脉粥样瘤的沉积。新出现的证据表明，针对这些病原体毒力因子的疫苗接种和抗炎治疗可能赋予疾病抵抗力。在本综述中，我们重点关注炎症机制和氧化修饰在牙龈卟啉单胞菌或伴放线聚集杆菌加速的ApoE基因缺陷小鼠模型和高脂饮食喂养小鼠动脉粥样硬化斑块形成和激活中的作用。此外，我们研究了用牙周病原体进行黏膜疫苗接种或儿茶素的抗炎活性是否可以减轻牙周病原体加速的动脉粥样硬化。
