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乌榄的抗乙酰胆碱酯酶和抗利什曼原虫活性

The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq.

作者信息

Mogana R, Adhikari A, Debnath S, Hazra S, Hazra B, Teng-Jin K, Wiart C

机构信息

School of Pharmacy, Faculty of Science, Center for Natural and Medicinal Products Research, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor, Malaysia.

HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.

出版信息

Biomed Res Int. 2014;2014:903529. doi: 10.1155/2014/903529. Epub 2014 May 15.

DOI:10.1155/2014/903529
PMID:24949478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4053261/
Abstract

In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 μ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 μ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.

摘要

在我们关于热带雨林植物的天然和药用研究项目的延续中，对橄榄科植物显脉橄榄（Canarium patentinervium Miq.）叶片乙醇提取物进行生物活性导向的分离，得到了东莨菪素（1）、滨蒿内酯（2）、（+）-儿茶素（3）、vomifoliol（4）、lioxin（5）和丁香酸（6）。所有化合物均表现出抗乙酰胆碱酯酶活性，其中酚酸丁香酸表现出良好的乙酰胆碱酯酶抑制作用（IC50 29.53±0.19μg/mL）。所有化合物均表现出中等程度的抗利什曼原虫活性，其中东莨菪素具有最高的抗利什曼原虫活性（IC50 163.30±0.32μg/mL）。鉴于上述证据，不禁推测显脉橄榄可能是开发治疗神经退行性疾病和寄生虫病药物先导物的一个令人兴奋的骨架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/0d708acc60fd/BMRI2014-903529.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/8e2f0d581004/BMRI2014-903529.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/fefb0c241d61/BMRI2014-903529.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/0d708acc60fd/BMRI2014-903529.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/8e2f0d581004/BMRI2014-903529.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/fefb0c241d61/BMRI2014-903529.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/4053261/0d708acc60fd/BMRI2014-903529.003.jpg

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