肌浆联蛋白提供了一种新颖的基于肌肉的适应性生热机制。
Sarcolipin provides a novel muscle-based mechanism for adaptive thermogenesis.
机构信息
Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
出版信息
Exerc Sport Sci Rev. 2014 Jul;42(3):136-42. doi: 10.1249/JES.0000000000000016.
PMID:24949847
Abstract
The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) transports Ca into the sarcoplasmic reticulum lumen and contributes significantly to skeletal muscle metabolic rate. Sarcolipin (SLN) has been shown recently to uncouple Ca transport from adenosine triphosphate hydrolysis by SERCA. We have hypothesized that SLN provides a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity.
摘要
肌浆网 Ca-ATP 酶（SERCA）将 Ca 转运到肌浆网腔中，对骨骼肌代谢率有重要贡献。最近已经表明，肌浆素（SLN）通过 SERCA 将 Ca 转运与三磷酸腺苷水解解偶联。我们假设 SLN 为骨骼肌内适应性生热提供了一种新的机制，并防止了饮食诱导的肥胖。
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