University of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA.
University of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA.
Immunity. 2014 Jun 19;40(6):857-8. doi: 10.1016/j.immuni.2014.06.002.
In this issue of Immunity, Visvikis et al. (2014) use the model host Caenorhabditis elegans to discover a role in innate immunity for the basic helix-loop-helix transcription factor, HLH-30. The finding inspires study of the mammalian ortholog TFEB, in which a similar role in immune response is ascertained.
在本期《免疫》中，Visvikis 等人（2014）利用模式宿主秀丽隐杆线虫发现了基本螺旋-环-螺旋转录因子 HLH-30 在先天免疫中的作用。这一发现启发了对哺乳动物同源物 TFEB 的研究，在 TFEB 中也确定了其在免疫反应中的类似作用。
