Department of Anesthesiology, The First Affiliated Hospital, China Medical University, 110001 NO,155 of Nanjingbei Street, Heping District, Shenyang, Liaoning Province, People's Republic of China.
J Headache Pain. 2014 Jun 20;15(1):42. doi: 10.1186/1129-2377-15-42.
To investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients.
A total of 244 TN patients and 280 age and sex matched healthy volunteer were recruited. 5-HTTLPR and rs 25531 genotyping were performed. All patients received the carbamazepine treatment and the treatment response was evaluated at 6 months.
The genotype distribution of 5-HTTLPR between TN patients and controls were significantly different. The TN Patients had a higher prevalence of short-short genotype than controls. The short-short genotype carriers are also significantly associated with higher pain severity and poorer carbamazepine treatment response compared to the long-long genotype carriers. In contrast, the rs 25531 polymorphism was not associated with the susceptibility to TN, neither with the pain severity and the treat response to carbamazepine.
The 5-HTTLPR polymorphism is associated with the susceptibility to TN and pain severity of TN.
为了探究 5-羟色胺转运体基因（5-HTTLPR）和 rs25531 多态性与三叉神经痛（TN）患者的易感性和疼痛严重程度之间的可能关联。
共纳入 244 例 TN 患者和 280 名年龄和性别相匹配的健康志愿者。进行 5-HTTLPR 和 rs25531 基因分型。所有患者均接受卡马西平治疗，并在 6 个月时评估治疗反应。
TN 患者与对照组之间 5-HTTLPR 的基因型分布存在显著差异。TN 患者的短-短基因型的发生率明显高于对照组。与长-长基因型携带者相比，短-短基因型携带者的疼痛严重程度更高，且对卡马西平的治疗反应更差。相比之下，rs25531 多态性与 TN 的易感性、疼痛严重程度和卡马西平治疗反应均无相关性。
5-HTTLPR 多态性与 TN 的易感性和疼痛严重程度相关。
