5-羟色胺转运体基因多态性与特发性三叉神经痛患者的易感性和疼痛严重程度相关。
The serotonin transporter gene polymorphism is associated with the susceptibility and the pain severity in idiopathic trigeminal neuralgia patients.
机构信息
Department of Anesthesiology, The First Affiliated Hospital, China Medical University, 110001 NO,155 of Nanjingbei Street, Heping District, Shenyang, Liaoning Province, People's Republic of China.
出版信息
J Headache Pain. 2014 Jun 20;15(1):42. doi: 10.1186/1129-2377-15-42.
Abstract
BACKGROUND
To investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients.
METHODS
A total of 244 TN patients and 280 age and sex matched healthy volunteer were recruited. 5-HTTLPR and rs 25531 genotyping were performed. All patients received the carbamazepine treatment and the treatment response was evaluated at 6 months.
RESULTS
The genotype distribution of 5-HTTLPR between TN patients and controls were significantly different. The TN Patients had a higher prevalence of short-short genotype than controls. The short-short genotype carriers are also significantly associated with higher pain severity and poorer carbamazepine treatment response compared to the long-long genotype carriers. In contrast, the rs 25531 polymorphism was not associated with the susceptibility to TN, neither with the pain severity and the treat response to carbamazepine.
CONCLUSION
The 5-HTTLPR polymorphism is associated with the susceptibility to TN and pain severity of TN.
摘要
背景
为了探究 5-羟色胺转运体基因（5-HTTLPR）和 rs25531 多态性与三叉神经痛（TN）患者的易感性和疼痛严重程度之间的可能关联。
方法
共纳入 244 例 TN 患者和 280 名年龄和性别相匹配的健康志愿者。进行 5-HTTLPR 和 rs25531 基因分型。所有患者均接受卡马西平治疗，并在 6 个月时评估治疗反应。
结果
TN 患者与对照组之间 5-HTTLPR 的基因型分布存在显著差异。TN 患者的短-短基因型的发生率明显高于对照组。与长-长基因型携带者相比，短-短基因型携带者的疼痛严重程度更高，且对卡马西平的治疗反应更差。相比之下，rs25531 多态性与 TN 的易感性、疼痛严重程度和卡马西平治疗反应均无相关性。
结论
5-HTTLPR 多态性与 TN 的易感性和疼痛严重程度相关。
相似文献
1
The serotonin transporter gene polymorphism is associated with the susceptibility and the pain severity in idiopathic trigeminal neuralgia patients.5-羟色胺转运体基因多态性与特发性三叉神经痛患者的易感性和疼痛严重程度相关。
J Headache Pain. 2014 Jun 20;15(1):42. doi: 10.1186/1129-2377-15-42.
2
Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans.血清素转运体基因（5-HTTLPR，rs25531）的基因变异会影响人体对短效阿片类药物瑞芬太尼的镇痛反应。
Mol Pain. 2009 Jul 1;5:37. doi: 10.1186/1744-8069-5-37.
3
Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression.血清素转运体（5-HTTLPR）和去甲肾上腺素转运体（NET）基因多态性：难治性抑郁症中电休克治疗的易感性及治疗反应
Neurosci Lett. 2015 Mar 17;590:116-20. doi: 10.1016/j.neulet.2015.01.077. Epub 2015 Feb 1.
4
Familial occurrence of classical and idiopathic trigeminal neuralgia.家族性经典性和特发性三叉神经痛。
J Neurol Sci. 2022 Mar 15;434:120101. doi: 10.1016/j.jns.2021.120101. Epub 2021 Dec 22.
5
The serotonin transporter gene polymorphism (5-HTTLPR) and affective symptoms among women diagnosed with borderline personality disorder.诊断为边缘型人格障碍的女性中，5-羟色胺转运体基因多态性（5-HTTLPR）与情感症状的关系。
Eur Psychiatry. 2010 Jan;25(1):19-25. doi: 10.1016/j.eurpsy.2009.05.001. Epub 2009 Aug 20.
6
Trigeminal neuralgia and genetics: A systematic review.三叉神经痛与遗传学：系统综述。
Mol Pain. 2021 Jan-Dec;17:17448069211016139. doi: 10.1177/17448069211016139.
7
No association between the serotonin transporter linked polymorphic region polymorphism and severity of posttraumatic stress disorder symptoms in combat veterans with or without comorbid depression.没有发现与创伤后应激障碍症状严重程度相关的 5-羟色胺转运体基因多态性与战斗老兵中是否共患抑郁症之间存在关联。
Psychiatry Res. 2016 Oct 30;244:376-81. doi: 10.1016/j.psychres.2016.08.017. Epub 2016 Aug 8.
8
No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia.Nav1.7 或神经生长因子受体基因多态性与三叉神经痛无关。
Pain Med. 2019 Jul 1;20(7):1362-1369. doi: 10.1093/pm/pny191.
9
Genetic association analysis of serotonin transporter polymorphism (5-HTTLPR) with type 2 diabetes patients of Pakistani population.巴基斯坦人群2型糖尿病患者血清素转运体基因多态性（5-HTTLPR）的遗传关联分析。
Diabetes Res Clin Pract. 2015 Apr;108(1):67-71. doi: 10.1016/j.diabres.2015.01.009. Epub 2015 Jan 20.
10
Atrophic changes in the trigeminal nerves of patients with trigeminal neuralgia due to neurovascular compression and their association with the severity of compression and clinical outcomes.神经血管压迫所致三叉神经痛患者三叉神经的萎缩性改变及其与压迫严重程度和临床结局的关联。
J Neurosurg. 2014 Jun;120(6):1484-95. doi: 10.3171/2014.2.JNS131288. Epub 2014 Apr 18.
引用本文的文献
1
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia.英国生物库队列中的基因组验证表明 C8B 和 MFG-E8 在三叉神经痛发病机制中的作用。
J Mol Neurosci. 2024 Oct 3;74(4):91. doi: 10.1007/s12031-024-02263-x.
2
Exploring causal correlations between plasma proteins and peripheral neuropathy: a Mendelian randomization.探索血浆蛋白与周围神经病变之间的因果关系：孟德尔随机化研究
Front Neurol. 2024 Aug 29;15:1431669. doi: 10.3389/fneur.2024.1431669. eCollection 2024.
3
Role of HDAC5 Epigenetics in Chronic Craniofacial Neuropathic Pain.组蛋白去乙酰化酶 5 的表观遗传学在慢性颅面部神经性疼痛中的作用。
Int J Mol Sci. 2024 Jun 23;25(13):6889. doi: 10.3390/ijms25136889.
4
Trigeminal neuralgia.三叉神经痛
Nat Rev Dis Primers. 2024 May 30;10(1):39. doi: 10.1038/s41572-024-00523-z.
5
Serotonin Transporter (5-Hydroxytryptamine Transporter, SERT, SLC6A4) and Sodium-dependent Reuptake Inhibitors as Modulators of Pain Behaviors and Analgesic Responses.血清素转运体（5-羟色胺转运体，SERT，SLC6A4）及钠依赖性再摄取抑制剂作为疼痛行为和镇痛反应的调节剂
J Pain. 2024 Mar;25(3):618-631. doi: 10.1016/j.jpain.2023.10.008. Epub 2023 Oct 16.
6
Effect of common OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 polymorphisms on perioperative analgesic and propofol demands on patients subjected to thyroidectomy surgery.常见 OPRM1、COMT、SLC6A4、ABCB1 和 CYP2B6 多态性对甲状腺切除术患者围手术期镇痛和丙泊酚需求的影响。
Pharmacol Rep. 2023 Apr;75(2):386-396. doi: 10.1007/s43440-023-00455-7. Epub 2023 Feb 7.
7
Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea.三叉神经痛的流行病学：韩国的一项电子人群健康数据研究。
Korean J Pain. 2021 Jul 1;34(3):332-338. doi: 10.3344/kjp.2021.34.3.332.
8
Trigeminal neuralgia and genetics: A systematic review.三叉神经痛与遗传学：系统综述。
Mol Pain. 2021 Jan-Dec;17:17448069211016139. doi: 10.1177/17448069211016139.
9
Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus.血清素转运体基因多态性对2型糖尿病患者肠道蠕动的影响。
J Neurogastroenterol Motil. 2021 Apr 30;27(2):240-247. doi: 10.5056/jnm20211.
10
Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.外显子组测序表明三叉神经痛中γ-氨基丁酸信号传导受损和神经元离子转运异常。
iScience. 2020 Sep 11;23(10):101552. doi: 10.1016/j.isci.2020.101552. eCollection 2020 Oct 23.
本文引用的文献
1
Pain in trigeminal neuralgia: neurophysiology and measurement: a comprehensive review.三叉神经痛中的疼痛：神经生理学与测量：全面综述
J Med Life. 2013;6(4):383-8. Epub 2013 Dec 25.
2
The effect of the polymorphisms of 5-HTTLPR on new onset of depression in patients who underwent pacemaker implantation.5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）多态性对接受起搏器植入患者新发抑郁症的影响。
Psychiatr Genet. 2014 Apr;24(2):70-4. doi: 10.1097/YPG.0000000000000012.
3
Behavioural genetics of the serotonin transporter.血清素转运体的行为遗传学
Curr Top Behav Neurosci. 2012;12:503-35. doi: 10.1007/7854_2011_186.
4
Trigeminal neuralgia: diagnosis and treatment.三叉神经痛：诊断与治疗
World Neurosurg. 2011 Dec;76(6):533-4. doi: 10.1016/j.wneu.2011.06.028.
5
Neurosurgical treatment of trigeminal neuralgia.三叉神经痛的神经外科治疗
Dis Mon. 2011 Oct;57(10):570-82. doi: 10.1016/j.disamonth.2011.09.003.
6
Effects of carbamazepine/oxycodone coadministration in the treatment of trigeminal neuralgia.卡马西平/羟考酮联合治疗三叉神经痛的效果。
Ann Pharmacother. 2011 Jun;45(6):e33. doi: 10.1345/aph.1Q013. Epub 2011 Jun 7.
7
Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine.拉莫三嗪与卡马西平治疗三叉神经痛的疗效和安全性比较。
J Chin Med Assoc. 2011 Jun;74(6):243-9. doi: 10.1016/j.jcma.2011.04.002. Epub 2011 May 10.
8
A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C).一项对 5-羟色胺能通路基因的候选基因研究显示，在使用依他普仑治疗神经性疼痛的患者中，疼痛缓解与 5-羟色胺受体 2C（HTR2C）显著相关。
Eur J Clin Pharmacol. 2011 Nov;67(11):1131-7. doi: 10.1007/s00228-011-1056-x. Epub 2011 May 26.
9
Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.条件性疼痛调制与 5-羟色胺转运体基因的常见多态性有关。
PLoS One. 2011 Mar 28;6(3):e18252. doi: 10.1371/journal.pone.0018252.
10
Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.对热痛的感知和热格栅错觉与 5-羟色胺转运体基因的多态性有关。
PLoS One. 2011 Mar 15;6(3):e17752. doi: 10.1371/journal.pone.0017752.
Zotero 插件