Sriwardhana K B, Howard A J, Dunkin K T
Gwynedd District General Hospital, Penrhosgarnedd, Bangor, North Wales.
J Laryngol Otol. 1989 Mar;103(3):253-6. doi: 10.1017/s0022215100108631.
A study was undertaken to evaluate the prevalence and antibiotic susceptibility of bacteria present in the middle ear of patients with otitis media with effusion. Middle ear effusions (MEE), nasopharyngeal and throat swabs were obtained at operation and cultured for aerobic and anaerobic bacteria. Two hundred and fifty-nine effusions were obtained from 152 subjects examined. Haemophilus influenzae was isolated from 32 (12.3 per cent) effusions, Streptococcus pneumoniae from seven (2.7 per cent), Staphylococcus aureus from seven (2.7 per cent), Branhamella catarrhalis from one (0.4 per cent)--Group A beta haemolytic streptococci from one (0.4 per cent) and Staphylococcus epidermidis from three (1.9 per cent). The occurrence of respiratory pathogens in MEE reflected their prevalence in the upper respiratory tract. Significantly fewer children who had received antibiotics prior to surgery had organisms present in the MEE. Eight and a half per cent of H. influenzae and 64 per cent of B. catarrhalis were resistant to ampicillin. The present study confirms that bacteria are present in the middle ear in a significant number of patients with otitis media with effusion.
开展了一项研究，以评估分泌性中耳炎患者中耳内细菌的流行情况及抗生素敏感性。手术时获取中耳积液（MEE）、鼻咽和咽喉拭子，培养需氧菌和厌氧菌。从152名受检者身上获取了259份积液。在32份（12.3%）积液中分离出流感嗜血杆菌，7份（2.7%）中分离出肺炎链球菌，7份（2.7%）中分离出金黄色葡萄球菌，1份（0.4%）中分离出卡他布兰汉菌，1份（0.4%）中分离出A组β溶血性链球菌，3份（1.9%）中分离出表皮葡萄球菌。中耳积液中呼吸道病原体的出现反映了它们在上呼吸道中的流行情况。术前接受过抗生素治疗的儿童中耳积液中存在病原体的明显较少。8.5%的流感嗜血杆菌和64%的卡他布兰汉菌对氨苄西林耐药。本研究证实，大量分泌性中耳炎患者的中耳内存在细菌。
