Mills R P, Uttley A H, McIntyre M F
Clin Otolaryngol Allied Sci. 1985 Dec;10(6):335-41. doi: 10.1111/j.1365-2273.1985.tb00265.x.
Middle ear effusions and swabs from the external auditory meatus, nasopharynx and anterior nares have been collected from 100 children with chronic secretory otitis media. Isolates of Haemophilus influenzae and Streptococcus pneumoniae were typed and in vitro sensitivities to commonly used antibiotics were determined for these species and Staphylococcus aureus. Positive middle ear cultures were obtained from 21 children (27 effusions). Haemophilus influenzae and S. pneumoniae were the commonest organisms isolated, both from the middle ear and upper respiratory tract. When one or other of these species was isolated from the middle ear, the same organism was generally found in the upper respiratory tract, but not in the ear canal. The serotypes isolated from the different sites were also the same. Type 19 was the commonest Pneumococcal serotype isolated, while type e was the commonest capsulated strain of H. influenzae. Thirty-six per cent of strains of H. influenzae were resistant to penicillin and 25% of those of S. pneumoniae were resistant to trimethaprim. Eighty-one per cent of isolates of S. aureus were penicillin resistant. There was no difference in the incidence of either S. pneumoniae or H. influenzae in the post nasal spaces of children who had had their adenoids removed and those who had not.
从100名患有慢性分泌性中耳炎的儿童中采集了中耳积液以及外耳道、鼻咽和前鼻孔的拭子。对流感嗜血杆菌和肺炎链球菌的分离株进行了分型，并测定了这些菌种以及金黄色葡萄球菌对常用抗生素的体外敏感性。21名儿童（27份积液）的中耳培养结果呈阳性。流感嗜血杆菌和肺炎链球菌是中耳和上呼吸道分离出的最常见病原体。当中耳分离出其中一种菌种时，通常在上呼吸道也能发现相同的病原体，但在耳道中则未发现。从不同部位分离出的血清型也相同。19型是分离出的最常见肺炎球菌血清型，而e型是流感嗜血杆菌最常见的有荚膜菌株。36%的流感嗜血杆菌菌株对青霉素耐药，25%的肺炎链球菌菌株对甲氧苄啶耐药。81%的金黄色葡萄球菌分离株对青霉素耐药。腺样体切除儿童和未切除儿童的鼻咽部肺炎链球菌或流感嗜血杆菌的发生率没有差异。
