Lee Alice C Y, Hostetler Joseph A, Bowman Dwight D
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Bayer HealthCare LLC, Veterinary Services, Shawnee Mission, KS, USA.
Vet Parasitol. 2014 Aug 29;204(3-4):402-6. doi: 10.1016/j.vetpar.2014.05.028. Epub 2014 May 23.
Endoscopic capsules and endoscopy were used to assess the speed of kill and the clearance of hookworms in dogs experimentally infected with Ancylostoma caninum. A total of four adult dogs were inoculated in two separate cohorts comprised of two 4-year-old females and two 7-year-old males. Dogs were treated topically with Advantage Multi(®) for Dogs 13 days (Cohort 1) or 16 days (Cohort 2) after infection. Endoscopic imaging of the small intestine was carried out both pre- and post-treatment. Examination of the first cohort revealed that the worms had been cleared and the hookworm-induced lacerations were markedly diminished within 48 h of treatment. In the second cohort, endoscopic capsules were given the day of, the day after, and two days after treatment; within 24h of product administration, the worms had been removed with a concurrent reduction in observed lesions. Topical application of Advantage Multi(®) for Dogs rapidly removed worms from the small intestine of the dogs in this study as early as 24h post-treatment, with a marked reduction in the number of mucosal lesions seen.
使用内窥镜胶囊和内窥镜检查来评估感染犬弓首蛔虫的实验犬体内钩虫的杀灭速度和清除情况。总共四只成年犬被分为两个独立的组，一组由两只4岁雌性犬组成，另一组由两只7岁雄性犬组成。感染后13天（第1组）或16天（第2组），用宠物用拜宠爽（Advantage Multi(®) for Dogs）对犬进行局部治疗。在治疗前和治疗后都对小肠进行了内窥镜成像检查。对第一组的检查显示，在治疗后48小时内，蠕虫已被清除，钩虫引起的撕裂伤明显减轻。在第二组中，在治疗当天、治疗后一天和治疗后两天给予内窥镜胶囊；在给药后24小时内，蠕虫已被清除，同时观察到的病变有所减少。在本研究中，局部应用宠物用拜宠爽（Advantage Multi(®) for Dogs）可在治疗后24小时内迅速从犬的小肠中清除蠕虫，同时可见粘膜损伤数量显著减少。
