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采用自体心包对60岁以下患者进行主动脉瓣重建。

Aortic valve reconstruction using autologous pericardium for patients aged less than 60 years.

作者信息

Ozaki Shigeyuki, Kawase Isamu, Yamashita Hiromasa, Nozawa Yukinari, Takatoh Mikio, Hagiwara So, Kiyohara Nagaki

机构信息

Department of Cardiovascular Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.

Department of Cardiovascular Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.

出版信息

J Thorac Cardiovasc Surg. 2014 Sep;148(3):934-8. doi: 10.1016/j.jtcvs.2014.05.041. Epub 2014 May 21.

Abstract

OBJECTIVE

We have performed an original aortic valve reconstruction using autologous pericardium. The feasibility for patients aged less than 60 years is reviewed.

METHODS

From April 2007 to April 2013, aortic valve reconstruction was performed in 108 patients aged less than 60 years. A total of 51 patients had aortic stenosis, 7 patients had annuloaortic ectasia, 7 patients had infective endocarditis, and 43 patients had aortic regurgitation. Fifty-seven patients had bicuspid valves, and 11 patients had unicuspid valves. There were 75 male and 33 female patients, with a mean age of 47.8 ± 11.2 years. Preoperative echocardiography showed an average peak pressure gradient of 86.1 ± 35.1 mm Hg with aortic stenosis. The surgical procedure is based on the independent tricuspid replacement using autologous pericardium. First, the distance between the commissures is measured using an original sizing apparatus, and then the pericardial cusp is trimmed using an original template and sutured to the annulus.

RESULTS

There was no conversion to prosthetic valve replacement. There were no in-hospital mortalities. Postoperative echocardiography showed an average peak pressure gradient of 14.8 ± 7.8 mm Hg 1 week after surgery and 12.8 ± 3.1 mm Hg 4 years after surgery. One patient required reoperation because of infective endocarditis. The other 107 patients showed less than mild aortic regurgitation. No thromboembolic events were recorded. The mean follow-up period was 34.2 ± 15.7 months. Freedom from reoperation was 98.9% with 76 months of follow-up.

CONCLUSIONS

Original aortic valve reconstruction was feasible for patients aged less than 60 years. Long-term data will be disclosed in the future.

摘要

目的

我们采用自体心包进行了一项原创性主动脉瓣重建手术。对60岁以下患者的可行性进行了评估。

方法

2007年4月至2013年4月,对108例60岁以下患者进行了主动脉瓣重建手术。其中51例为主动脉瓣狭窄,7例为主动脉瓣环扩张,7例为感染性心内膜炎,43例为主动脉瓣关闭不全。57例患者为二叶式主动脉瓣,11例为单叶式主动脉瓣。男性75例,女性33例,平均年龄47.8±11.2岁。术前超声心动图显示主动脉瓣狭窄患者平均峰值压力阶差为86.1±35.1 mmHg。手术方法基于使用自体心包进行独立的三尖瓣置换。首先,使用原创的测量装置测量瓣叶交界之间的距离,然后使用原创模板修剪心包瓣叶并缝合至瓣环。

结果

无转为人工瓣膜置换的情况。无院内死亡病例。术后超声心动图显示术后1周平均峰值压力阶差为14.8±7.8 mmHg,术后4年为12.8±3.1 mmHg。1例患者因感染性心内膜炎需要再次手术。其他107例患者显示主动脉瓣反流程度小于轻度。未记录到血栓栓塞事件。平均随访时间为34.2±15.7个月。随访76个月时再次手术的自由度为98.9%。

结论

原创性主动脉瓣重建对60岁以下患者是可行的。长期数据将在未来公布。

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