Wu Xiaotong, Li Chunxia, Liao Suchan, Li Lu, Wang Tingting, Su Zhongmin, Wang Chungang, Zhao Jihong, Sui Changping, Lin Jun
Faculty of Chemistry, Northeast Normal University, Changchun, 130024 (P.R. China).
Chemistry. 2014 Jul 14;20(29):8876-82. doi: 10.1002/chem.201403202. Epub 2014 Jun 20.
Gd(3+)-aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd(3+)-A-AuNCs@SiO2NPs) were strategically designed and prepared. The as-prepared nanoparticles exhibit aggregation-enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters served as novel nanoprobes for in vitro and in vivo multimodal (fluorescence, magnetic resonance, and computed X-ray tomography) cancer imaging.
通过策略性设计和制备了由二氧化硅壳包裹的钆（III）聚集金纳米簇（Gd(3+)-A-AuNCs@SiO2NPs）。所制备的纳米粒子表现出聚集增强荧光（AEF），其强度高达离散金纳米簇的3.8倍。这些纳米簇作为新型纳米探针用于体外和体内多模态（荧光、磁共振和计算机X射线断层扫描）癌症成像。
