Cellini Nicola, de Zambotti Massimiliano, Covassin Naima, Sarlo Michela, Stegagno Luciano
Department of General Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy.
Department of General Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy; Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park 94043, CA, USA.
Neurobiol Learn Mem. 2014 Oct;114:141-7. doi: 10.1016/j.nlm.2014.06.006. Epub 2014 Jun 19.
Compelling evidence indicates that sleep can facilitate the off-line consolidation of declarative, perceptual, emotional and procedural memories. Here we assessed the sleep-related off-line consolidation of motor skills in 13 young primary insomniacs (23.31±2.5 yrs) compared to 13 healthy sleepers (24.31±1.6 yrs) using the sequential finger tapping task. During a training session insomniacs performed less correct sequences than controls. However, both groups exhibited similar on-line motor learning in the pre-sleep evening session. After a night of sleep, healthy controls improved their performance, indicating an overnight effect of sleep on motor skills consolidation. In contrast, insomniacs failed to exhibit a sleep-related enhancement in memory performance indicating impairment in the off-line motor skills consolidation process. Our results suggest that young adults with insomnia experience impaired off-line memory consolidation which seems not to be associated with reduced ability to acquire new motor information.
有力证据表明，睡眠有助于陈述性、感知性、情感性和程序性记忆的离线巩固。在此，我们使用连续手指敲击任务，评估了13名年轻原发性失眠症患者（23.31±2.5岁）与13名健康睡眠者（24.31±1.6岁）中与睡眠相关的运动技能离线巩固情况。在一次训练中，失眠症患者完成的正确序列比对照组少。然而，两组在睡前晚间训练中都表现出相似的在线运动学习能力。经过一夜睡眠后，健康对照组的表现有所改善，表明睡眠对运动技能巩固有过夜效应。相比之下，失眠症患者在记忆表现上未能表现出与睡眠相关的增强，表明离线运动技能巩固过程受损。我们的结果表明，患有失眠症的年轻人经历了离线记忆巩固受损，这似乎与获取新运动信息的能力降低无关。
