Ulutas Kemal Turker, Dokuyucu Recep, Sefil Fatih, Yengil Erhan, Sumbul Ahmet Taner, Rizaoglu Hatice, Ustun Ihsan, Yula Erkan, Sabuncu Tevfik, Gokce Cumali
Department of Biochemistry, Kadirli State Hospital Osmaniye, Turkey.
Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
Int J Clin Exp Med. 2014 Apr 15;7(4):955-61. eCollection 2014.
Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA1c and duration of diabetes in the diabetic patients, respectively.
The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA1c levels: group A consisted of patients with HbA1c levels ≤7% and group B consisted of patients with HbA1c levels >7%.
MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA1c and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM.
Our findings suggested an association between MPV and HbA1c. Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.
血小板在动脉粥样硬化和动脉血栓形成中起重要作用。2型糖尿病（2型DM）的心血管并发症患病率可能与糖化血红蛋白（HbA1c）和平均血小板体积（MPV）有关。本研究的目的是通过测量糖尿病患者与非糖尿病患者的MPV，调查糖尿病及其相关血管并发症中血小板是否被激活，并分别确定糖尿病患者中MPV与空腹血糖（FSG）、HbA1c和糖尿病病程的相关性。
该研究纳入了65例2型糖尿病患者和40例非糖尿病受试者。除了非糖尿病患者外，所有糖尿病患者根据其HbA1c水平分为两组：A组由HbA1c水平≤7%的患者组成，B组由HbA1c水平>7%的患者组成。
与非糖尿病患者和A组相比，B组的MPV显著更高。MPV与HbA1c、FSG以及糖尿病病程均呈高度正相关。研究发现2型糖尿病患者的MPV升高。
我们的研究结果表明MPV与HbA1c之间存在关联。因此，MPV可能是2型糖尿病患者心血管并发症的一个有益的预后标志物。
