Tihić-Kapidžić Suzana, Čaušević Adlija, Fočo-Solak Jasmina, Malenica Maja, Dujić Tanja, Hasanbegović Sniježana, Babić Nermina, Begović Ermin
University of Sarajevo, Clinical Centre, Department for Clinical Biochemistry and Immunology, Sarajevo, Bosnia and Herzegovina.
University of Sarajevo, Faculty of Pharmacy, Department of Biochemistry and Clinical Analysis, Sarajevo, Bosnia and Herzegovina.
J Med Biochem. 2021 Mar 12;40(2):181-192. doi: 10.5937/jomb0-25315.
Altered levels of many hematological parameters have been directly associated with diabetes in adults, while studies on children with type 1 diabetes mellitus are lacking. The aim of this study was to determine hematological indices in diabetic Bosnian children in comparison to healthy controls as well as to correlate their levels to blood glucose and hemoglobin A1c.
100 healthy and 100 children with type 1 diabetes mellitus (age 1-18) were included in this study. Complete blood count, hemoglobin A1c, and glucose were tested. Results were analysed by IBM SPSS Statistics version 23.
Significant differences (p<0.05) between healthy and diabetic children were found in relation to HbA1c, glucose, mean platelet volume, the number of white blood cells and erythrocytes, hematocrit, hemoglobin and MCH values. No gender differences or significant age differences were seen for hemoglobin, hematocrit, and MCV, while platelets, MPV, and MCH differed by age only in healthy children. When diabetic children were classified according to HbA1c levels, significant differences were seen for erythrocyte count and hematocrit value (p=0.013 and 0.019, respectively). The number of erythrocytes and white blood cells correlated significantly with HbA1c (p=0.037 and 0.027, respectively).
Lower levels of erythrocytes, hematocrit, and hemoglobin in diabetic compared to healthy children indicate possible development of anemia, while higher MCV, MCH, and MPV values indicate an alteration in erythrocyte morphology. Hematological indices could be a useful inexpensive tool in the diagnosis and follow up of type 1 diabetes in children.
许多血液学参数水平的改变已与成人糖尿病直接相关，而关于1型糖尿病儿童的研究却很缺乏。本研究的目的是确定波斯尼亚糖尿病儿童的血液学指标，并与健康对照组进行比较，同时将这些指标与血糖和糖化血红蛋白水平相关联。
本研究纳入了100名健康儿童和100名1型糖尿病儿童（年龄1 - 18岁）。检测了全血细胞计数、糖化血红蛋白和血糖。结果采用IBM SPSS Statistics 23版软件进行分析。
在糖化血红蛋白、血糖、平均血小板体积、白细胞和红细胞数量、血细胞比容、血红蛋白和平均红细胞血红蛋白含量值方面，健康儿童和糖尿病儿童之间存在显著差异（p<0.05）。血红蛋白、血细胞比容和平均红细胞体积在性别和年龄上无显著差异，而血小板、平均血小板体积和平均红细胞血红蛋白含量仅在健康儿童中随年龄有所不同。当根据糖化血红蛋白水平对糖尿病儿童进行分类时，红细胞计数和血细胞比容值存在显著差异（分别为p = 0.013和0.019）。红细胞和白细胞数量与糖化血红蛋白显著相关（分别为p = 0.037和0.027）。
与健康儿童相比，糖尿病儿童红细胞、血细胞比容和血红蛋白水平较低表明可能发生贫血，而较高的平均红细胞体积、平均红细胞血红蛋白含量和平均血小板体积值表明红细胞形态发生改变。血液学指标可能是儿童1型糖尿病诊断和随访中一种有用且廉价的工具。
