Islam Shafiqul, Yakout Sobhy M, Daghri Nasser M Al, Alhomida Abdullah S, Khan Haseeb A
Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
Biomarkers Research Lab, Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
Int J Clin Exp Med. 2014 Apr 15;7(4):1059-63. eCollection 2014.
Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro- and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
组织型纤溶酶原激活剂（TPA）和纤溶酶原激活剂抑制剂-1（PAI-1）分别具有促纤溶和抗纤溶活性。净纤溶活性主要由TPA和PAI-1水平之间的平衡决定。鉴于这些标志物在血栓形成途径中的重要作用，我们测定了50例急性心肌梗死（AMI）患者、100例伴有危险因素（血脂异常和高血压）的患者以及100例健康对照者血清中TPA和PAI-1的水平。研究结果显示，与对照受试者相比，AMI患者血清中TPA和PAI-1水平显著升高。在风险组中，这两种标志物仅略有升高，无统计学意义。体重指数与这些标志物之间无相关性，然而TPA和PAI-1分别与年龄和收缩压显著相关。总之，这些标志物的联合检测可为评估AMI的预后提供有用的工具。
