急性心肌梗死患者的血清血栓形成标志物水平。
Serum levels of thrombotic markers in patients with acute myocardial infarction.
作者信息
Islam Shafiqul, Yakout Sobhy M, Daghri Nasser M Al, Alhomida Abdullah S, Khan Haseeb A
机构信息
Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
Biomarkers Research Lab, Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
出版信息
Int J Clin Exp Med. 2014 Apr 15;7(4):1059-63. eCollection 2014.
Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro- and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
组织型纤溶酶原激活剂（TPA）和纤溶酶原激活剂抑制剂-1（PAI-1）分别具有促纤溶和抗纤溶活性。净纤溶活性主要由TPA和PAI-1水平之间的平衡决定。鉴于这些标志物在血栓形成途径中的重要作用，我们测定了50例急性心肌梗死（AMI）患者、100例伴有危险因素（血脂异常和高血压）的患者以及100例健康对照者血清中TPA和PAI-1的水平。研究结果显示，与对照受试者相比，AMI患者血清中TPA和PAI-1水平显著升高。在风险组中，这两种标志物仅略有升高，无统计学意义。体重指数与这些标志物之间无相关性，然而TPA和PAI-1分别与年龄和收缩压显著相关。总之，这些标志物的联合检测可为评估AMI的预后提供有用的工具。
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