Chen Jian, Lu Yingmin, Huang Damin, Luo Xiaohan, Zhang Yachen
Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
Int J Clin Exp Med. 2014 Apr 15;7(4):1122-7. eCollection 2014.
To explore the relationship of plasma osteopontin (OPN) level and renal function with severity of coronary artery lesions.
OPN level and renal function were detected and compared in 210 patients with coronary heart disease (CHD group) and 134 patients without coronary heart disease (control group) to analyze the relationship of osteopontin and renal function with severity of coronary artery lesions.
Plasma OPN and creatinine level were significantly higher in CHD group than those in control group (P<0.01), and estimated glomerular filtration rate (eGFR) was lower in CHD group than that in control group (P<0.01). The proportions of multi-vessel lesion and moderate to severe decreased renal function were higher in patients with high osteopontin than those in patients with low osteopontin (P<0.05), and the proportion of multi-vessel lesion was higher in patients with moderate to severe decreased renal function than that in normal renal function (P<0.05). Osteopontin and renal failure were the independent risk factors for coronary heart disease.
Plasma OPN level is associated with renal failure, both of which are correlated with the severity of coronary artery lesions.
探讨血浆骨桥蛋白（OPN）水平及肾功能与冠状动脉病变严重程度的关系。
检测并比较210例冠心病患者（冠心病组）和134例无冠心病患者（对照组）的OPN水平及肾功能，分析骨桥蛋白和肾功能与冠状动脉病变严重程度的关系。
冠心病组血浆OPN和肌酐水平显著高于对照组（P<0.01），且冠心病组的估计肾小球滤过率（eGFR）低于对照组（P<0.01）。骨桥蛋白水平高的患者多支血管病变及中重度肾功能下降的比例高于骨桥蛋白水平低的患者（P<0.05），中重度肾功能下降患者的多支血管病变比例高于肾功能正常者（P<0.05）。骨桥蛋白和肾衰竭是冠心病的独立危险因素。
血浆OPN水平与肾衰竭有关，二者均与冠状动脉病变严重程度相关。
