Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Int J Environ Res Public Health. 2022 Jan 2;19(1):477. doi: 10.3390/ijerph19010477.
By suppressing mineralization and preventing ectopic calcium deposits, osteopontin (OPN) has an inhibitory effect on vascular calcification. Also, there is an association between OPN and aortic stiffness (AS). We aimed to investigate the association between serum OPN levels and AS measured by carotid-femoral pulse wave velocity (cfPWV) in hypertensive patients. Baseline characteristics and fasting blood sampling of 120 participants with hypertension and 120 participants without hypertension were acquired. Serum OPN concentrations were determined by enzyme-linked immunosorbent assay. In total, 43 (35.9%) participants were assigned to the AS group with cfPWV of >10 m/s in hypertensive patients. There were more patients with diabetes mellitus, old age, high systolic blood pressure, high serum intact parathyroid hormone (iPTH), elevated C-reactive protein, and high OPN levels in the AS group compared with the control group in hypertensive participants. A multivariate logistic regression analysis discloses that age, SBP, serum OPN, and iPTH levels were independently associated with AS in hypertensive patients. Moreover, according to a multivariate forward stepwise linear regression analysis, OPN level is positively associated with cfPWV. In conclusion, serum OPN level is assumed to be a potential biomarker to predict AS and is positively associated with cfPWV in patients with hypertension.
骨桥蛋白（OPN）通过抑制矿化和防止异位钙沉积，对血管钙化具有抑制作用。此外，OPN 与主动脉僵硬（AS）之间存在关联。我们旨在研究高血压患者血清 OPN 水平与通过颈股脉搏波速度（cfPWV）测量的 AS 之间的关系。收集了 120 名高血压患者和 120 名无高血压患者的基线特征和空腹采血。通过酶联免疫吸附试验测定血清 OPN 浓度。在高血压患者中，共有 43 名（35.9%）患者的 cfPWV>10m/s，被分配到 AS 组。与对照组相比，高血压患者的 AS 组中，糖尿病、年龄较大、收缩压较高、血清全段甲状旁腺激素（iPTH）升高、C 反应蛋白升高和 OPN 水平升高的患者更多。多变量逻辑回归分析显示，年龄、SBP、血清 OPN 和 iPTH 水平与高血压患者的 AS 独立相关。此外，根据多变量向前逐步线性回归分析，OPN 水平与 cfPWV 呈正相关。总之，血清 OPN 水平可能是预测 AS 的潜在生物标志物，与高血压患者的 cfPWV 呈正相关。
