Chang Kai-Hsiang, Wang Chih-Hsien, Hsu Bang-Gee, Tsai Jen-Pi
Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Life (Basel). 2022 Mar 9;12(3):397. doi: 10.3390/life12030397.
Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Patients with cfPWV > 10 m/s were designated into the AS group. Results: Twenty-two patients (31.4%) were segregated into the AS group. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS. The receiver operating characteristic curve analysis showed that OPN was correlated with AS with an area under the curve of 0.903 (95% CI 0.809−0.961, p < 0.001). Conclusions: For PD patients, the serum OPN level was correlated with cfPWV and could play an important role in the process of AS.
骨桥蛋白（OPN）被认为是一种与动脉粥样硬化相关的促炎和促动脉粥样硬化分子。我们旨在评估腹膜透析（PD）患者血清OPN与主动脉僵硬度（AS）之间的关系。方法：分别使用商用酶联免疫吸附测定试剂盒和经过验证的眼压计系统测量OPN和颈股脉搏波速度（cfPWV）。cfPWV>10 m/s的患者被纳入AS组。结果：22例患者（31.4%）被纳入AS组。多变量线性和逻辑回归分析表明，OPN与cfPWV显著相关，是AS的独立预测因子。受试者工作特征曲线分析表明，OPN与AS相关，曲线下面积为0.903（95%CI 0.809−0.961，p<0.001）。结论：对于PD患者，血清OPN水平与cfPWV相关，并且在AS过程中可能起重要作用。
