Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jesse Brown Veterans Affairs Medical Center, Neurology Service, 820 S Damen Ave, Damen Building, 9th floor, Chicago, IL, 60612, USA.
Curr Neurol Neurosci Rep. 2022 Sep;22(9):565-576. doi: 10.1007/s11910-022-01220-8. Epub 2022 Jul 22.
To comprehensively summarize the sleep pathologies associated with movement disorders, focusing on neurodegenerative diseases.
Mounting evidence has further implicated both sleep and circadian disruption in the pathophysiology of many movement disorders. In particular, recent data illuminate the mechanisms by which poor sleep quality and circadian dysfunction can exacerbate neurodegeneration. In addition, anti-IgLON5 disease is a recently described autoimmune disease with various symptoms that can feature prominent sleep disruption and parasomnia. Many movement disorders are associated with sleep and circadian rhythm disruption. Motor symptoms can cause sleep fragmentation, resulting in insomnia and excessive daytime sleepiness. Many neurodegenerative movement disorders involve brainstem pathology in regions close to or affecting nuclei that regulate sleep and wake. Further, commonly used movement medications may exacerbate sleep concerns. Providers should screen for and address these sleep symptoms to improve function and quality of life for patients and caregivers.
全面总结与运动障碍相关的睡眠病理学，重点关注神经退行性疾病。
越来越多的证据进一步表明，睡眠和昼夜节律紊乱与许多运动障碍的病理生理学有关。特别是，最近的数据阐明了睡眠质量差和昼夜功能障碍如何加剧神经退行性变的机制。此外，抗 IgLON5 病是一种最近描述的自身免疫性疾病，具有多种症状，可表现出明显的睡眠障碍和睡眠行为异常。许多运动障碍与睡眠和昼夜节律紊乱有关。运动症状会导致睡眠碎片化，导致失眠和白天过度嗜睡。许多神经退行性运动障碍涉及靠近或影响调节睡眠和觉醒的核的脑干病理学。此外，常用的运动药物可能会加重睡眠问题。提供者应筛查和解决这些睡眠症状，以改善患者和护理人员的功能和生活质量。
