Wu Baijian, Pei Xuan, Li Zhi-Yong
Department of Engineering Mechanics, Southeast University, Nanjing 210096, China.
School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.
ScientificWorldJournal. 2014;2014:417324. doi: 10.1155/2014/417324. Epub 2014 Apr 6.
Calcification is commonly believed to be associated with cardiovascular disease burden. But whether or not the calcifications have a negative effect on plaque vulnerability is still under debate.
Fatigue rupture analysis and the fatigue life were used to evaluate the rupture risk. An idealized baseline model containing no calcification was first built. Based on the baseline model, we investigated the influence of calcification on rupture path and fatigue life by adding a circular calcification and changing its location within the fibrous cap area. Results show that 84.0% of calcified cases increase the fatigue life up to 11.4%. For rupture paths 10D far from the calcification, the life change is negligible. Calcifications close to lumen increase more fatigue life than those close to the lipid pool. Also, calcifications in the middle area of fibrous cap increase more fatigue life than those in the shoulder area.
Calcifications may play a positive role in the plaque stability. The influence of the calcification only exists in a local area. Calcifications close to lumen may be influenced more than those close to lipid pool. And calcifications in the middle area of fibrous cap are seemly influenced more than those in the shoulder area.
钙化通常被认为与心血管疾病负担相关。但钙化是否对斑块易损性有负面影响仍存在争议。
采用疲劳破裂分析和疲劳寿命来评估破裂风险。首先构建了一个无钙化的理想化基线模型。基于该基线模型，通过添加圆形钙化并改变其在纤维帽区域内的位置，研究钙化对破裂路径和疲劳寿命的影响。结果显示，84.0%的钙化病例使疲劳寿命增加高达11.4%。对于距离钙化10D的破裂路径，寿命变化可忽略不计。靠近管腔的钙化比靠近脂质池的钙化增加更多的疲劳寿命。此外，纤维帽中间区域的钙化比肩部区域的钙化增加更多的疲劳寿命。
钙化可能在斑块稳定性中发挥积极作用。钙化的影响仅存在于局部区域。靠近管腔的钙化可能比靠近脂质池的钙化受到更大影响。并且纤维帽中间区域的钙化似乎比肩部区域的钙化受到更大影响。
