Trimaldi Janese A, Bowers Jeremy W, Bello Celeste, Sagatys Elizabeth M
Cancer Control. 2014 Jul;21(3):251-4. doi: 10.1177/107327481402100313.
A 68-year-old woman with a history of follicular lymphoma had pathological findings of grade 3B follicular lymphoma, mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL) identified in 1 lymph node. The DLBCL appeared to be a transformation of the follicular lymphoma. The nodules were diffusely and strongly positive for CD20, BCL6, and BCL2. CD43 highlighted smaller lymphocytes in a fraction of the nodules. BCL1 staining was variable with a mixture of nodular and mantle zone patterns. The diffuse areas showed weaker positivity for CD10, BCL2, and BCL6. CD3 and CD5 highlighted intermixed T cells. The Ki-67 proliferative index was overall estimated to be 60%. Fluorescent in situ hybridization performed on the lymph node was positive for CCND1/IGH. The patterns of BCL1 and BCL6 staining demonstrated 2 separate populations of neoplastic B lymphocytes.
一名有滤泡性淋巴瘤病史的68岁女性，在1个淋巴结中发现了3B级滤泡性淋巴瘤、套细胞淋巴瘤（MCL）和弥漫性大B细胞淋巴瘤（DLBCL）的病理表现。DLBCL似乎是滤泡性淋巴瘤的转化型。结节对CD20、BCL6和BCL2呈弥漫性强阳性。CD43在部分结节中突出显示较小的淋巴细胞。BCL1染色呈结节状和套区模式混合的可变表现。弥漫区域对CD10、BCL2和BCL6的阳性较弱。CD3和CD5突出显示混合的T细胞。Ki-67增殖指数总体估计为60%。对该淋巴结进行的荧光原位杂交显示CCND1/IGH呈阳性。BCL1和BCL6染色模式显示有2个独立的肿瘤性B淋巴细胞群体。
