[Study on the chemical constituents from the roots of Ligularia dentata in Henan].

OBJECTIVE

To study the chemical constituents from the roots of Ligularia dentata in Henna.

METHODS

Chemical constituents from the roots of Ligularia dentata in Henan were isolated and purified by silica gel, Sephadex LH-20 column chromatography and solvent crystallization and their structures were identified by spectral methods.

RESULTS

Four eremophilane-type sesquiterpenoids were obtained and determined as 3-oxo-8alpha-hydroxy-10alphaH-eremophilan-1,7-dien-8, 12beta-olide(1), 3-oxo-eremophil-1, 7-dien-8, 12beta-olide (2),3-oxo-8alpha-ethoxy-10alphaH-eremophil-1,7-dien-8,12-olide(3) and furanoligularenone(4).

CONCLUSION

Compound 1-4 are isolated from this plant for the first time and their contents in the roots are high by HPLC analysis except for compound 3. Compound 3 is hardly detected in the fresh EtOH extract and might be derived from other compounds during the extraction.