从箭叶橐吾中分离得到的萜类化合物

[Terpenoid compounds isolated from Ligularia sagitta].

作者信息

Liu Shou-jin, Zhang Mian, Wang Zheng-tao, Liu Jian-qun, Zhang Chao-feng

机构信息

Department of Pharmacognosy, China Phamraceutical University, Nanjing 210038, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(23):1965-7.

PMID:17348191

Abstract

OBJECTIVE

To study the chemical constituents of radix and rhizome of Ligularia sagitta.

METHOD

Isolation and purification were carried out on the column chromatography of silica gel and sephadex LH -20. The structures were identified by spectral analysis.

RESULT

Seven terpenoid compounds were isolated from the radix and rhizome of L. sagitta. Five of them are sesquiterpenoids, the structures were determined as 7alpha-hydroxy-9(10) -ene-1, 8-dioxo-6, 7-dihydrofuranoeremophilane (1), 1p, 10P3-epoxy-6beta, 8 beta-dihydroxy-eremophil7 (11) -en-12, 8alpha-olide (2) , 1-oxo-9-desoxycacalol (3), benzofuranoeremophil-l-ene (4) and bakkenolide (5); other two compounds belong to triterpenoid. 3p, 16P3-dihydroxy-12-oleanen-28-al (6) and lupeol (7).

CONCLUSION

Compoundsl-3 and 6 were: isolated from L. sagitta for the first time, and compounds 3 and 6 were obtained from Ligularia for the first time.

摘要

目的

研究箭叶橐吾根及根茎的化学成分。

方法

采用硅胶柱色谱和葡聚糖凝胶LH -20柱色谱进行分离纯化，通过波谱分析鉴定结构。

结果

从箭叶橐吾根及根茎中分离得到7个萜类化合物。其中5个为倍半萜类化合物，结构分别鉴定为7α-羟基-9(10)-烯-1,8-二氧代-6,7-二氢呋喃雅槛蓝烷(1)、1β,10β-环氧-6β,8β-二羟基-雅槛蓝-7(11)-烯-12,8α-内酯(2)、1-氧代-9-去氧卡克醇(3)、苯并呋喃雅槛蓝-1-烯(4)和蜂斗菜内酯(5)；另外2个化合物属于三萜类化合物，分别为3β,16β-二羟基-12-齐墩果烯-28-醛(6)和羽扇豆醇(7)。