Araki Yoshio, Takagi Yasushi, Ueda Keita, Ubukata Shiho, Ishida Junko, Funaki Takeshi, Kikuchi Takayuki, Takahashi Jun C, Murai Toshiya, Miyamoto Susumu
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto.
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto.
J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1789-94. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.032. Epub 2014 Jun 21.
Neurocognitive impairment is one of several unsolved social issues faced by patients with moyamoya disease. Although efforts have been made to investigate cognitive function using neuropsychologic tasks, generalizability has been limited. Here, in a preliminary study, we used structured neuropsychologic tasks to establish a standardized neuropsychologic assessment for adult moyamoya patients with and without difficulty in social independence.
Ten patients with neuroradiologically confirmed adult moyamoya disease (3 male, 7 female) participated. Half of all subjects did not have difficulty with social independence (group 1) and the others had (group 2). Group differences were evaluated after basic cognitive abilities and frontal lobe function were tested.
Although the mean age of group 1 was substantially higher than that of group 2, disease duration did not differ significantly between groups. Means scores for intelligence functions including all subtests for basic cognitive abilities were higher in group 1 compared with group 2. Scores from only 2 frontal lobe evaluation tasks (Trail Making Test B and Theory of Mind) were significantly different between groups.
This preliminary study provides a profile of neurocognitive dysfunction in adult patients with moyamoya disease using structured neuropsychologic tasks. A broad range of cognitive functions was disrupted particularly in the patients who had difficulty with social independence. To obtain stronger evidence regarding neurocognitive dysfunction in patients with moyamoya disease, a multicenter prospective study is essential.
神经认知障碍是烟雾病患者面临的几个未解决的社会问题之一。尽管已经努力使用神经心理学任务来研究认知功能，但其普遍性有限。在此，在一项初步研究中，我们使用结构化神经心理学任务为有或没有社会独立困难的成年烟雾病患者建立标准化神经心理学评估。
10例经神经放射学确诊的成年烟雾病患者（男3例，女7例）参与研究。所有受试者中有一半没有社会独立困难（第1组），另一半有（第2组）。在测试基本认知能力和额叶功能后评估组间差异。
虽然第1组的平均年龄显著高于第2组，但两组之间的病程无显著差异。与第2组相比，第1组包括所有基本认知能力子测试的智力功能平均得分更高。两组之间仅2项额叶评估任务（连线测验B和心理理论）的得分存在显著差异。
这项初步研究使用结构化神经心理学任务描述了成年烟雾病患者的神经认知功能障碍概况。广泛的认知功能受到干扰，特别是在有社会独立困难的患者中。为了获得关于烟雾病患者神经认知功能障碍的更有力证据，多中心前瞻性研究至关重要。
