Wang Chun-Ya, Zhao Pan, Liu Wei-Wei
Clinical Trial Center, Liver Failure Therapy and Research Center, Beijing 302 Hospital (PLA 302 Hospital), No,100 of West Fourth Ring Middle Road, Beijing 100039, China.
Ann Clin Microbiol Antimicrob. 2014 Jun 23;13:23. doi: 10.1186/1476-0711-13-23.
Few data can be available regarding acute liver failure (ALF) caused by severe acute hepatitis B up to now. This study aims to report such cases from China.
We conducted a multi-center investigation on ALF from 7 tertiary hospitals in different areas of China. A total of 11 patients with ALF caused by severe acute hepatitis B were finally identified. In these patients, there were 10 male and 1 female patients. As a serious complication, apparent hemorrhage occurred in 9 patients. Eventually, in these 11 patients, 4 survived and 7 died. 4 died of heavy bleeding, 2 died of systemic inflammatory response syndrome and 1 died of irreversible coma. No patients received liver transplantation.
ALF caused by severe acute hepatitis B is worthy of formal studies based on its rarity and severity.
迄今为止，关于严重急性乙型肝炎所致急性肝衰竭（ALF）的数据很少。本研究旨在报告来自中国的此类病例。
我们对中国不同地区7家三级医院的急性肝衰竭进行了多中心调查。最终确定了11例由严重急性乙型肝炎引起的急性肝衰竭患者。这些患者中，男性10例，女性1例。作为一种严重并发症，9例患者出现明显出血。最终，这11例患者中，4例存活，7例死亡。4例死于大出血，2例死于全身炎症反应综合征，1例死于不可逆昏迷。无一例患者接受肝移植。
严重急性乙型肝炎所致急性肝衰竭因其罕见性和严重性值得进行正式研究。
