Ríos Iván, Rovirosa Angeles, Morales Javier, Gonzalez-Farre Blanca, Arenas Meritxell, Ordi Jaume, Pahisa Jaume, Biete Albert
Radiation Oncology Department, Hospital clinic, Universitat de Barcelona, C/villarroel n° 170, 08036, Barcelona, Spain,
Arch Gynecol Obstet. 2014 Nov;290(5):993-7. doi: 10.1007/s00404-014-3311-8. Epub 2014 Jun 24.
Undifferentiated uterine sarcomas (UUS) are rare and aggressive tumor with scarce data on the outcome and best treatment. We aimed to describe the behavior among patients with UUS at our institution.
Thirteen patients with UUS treated in our centre from 1979 to 2010 were analyzed.
descriptive analysis for frequencies and Kaplan-Meier actuarial method for overall survival (OS).
Patients mean age was 66 years. Three had FIGO 2009 stage IA, five IB, two IIB, and three IVB. Ten patients underwent surgery and eight received postoperative radiotherapy. Three patients received adjuvant chemotherapy. The median follow-up was 16 months (2-276 months). Stage I patients developed two local relapses and three distant metastases (DM). DM was also observed in stage II patients and in 61.5 % of the entire series. Fifty percent of patients receiving radiotherapy remain alive without relapse. The median OS was 16 months, being 17 months for stage I and 9 for the remainder.
Poor outcome of UUS was associated with a high incidence of DM. Stage I had the best outcome. Radiotherapy seems to have benefited patients, with 100 % of local control and 50 % of long-term survivors. The high incidence of metastasis suggests the need for more accurate initial assessment.
未分化子宫肉瘤（UUS）是一种罕见且侵袭性强的肿瘤，关于其预后和最佳治疗的数据稀缺。我们旨在描述我院UUS患者的病情表现。
分析了1979年至2010年在我院接受治疗的13例UUS患者。
采用频率描述性分析和Kaplan-Meier精算方法计算总生存期（OS）。
患者平均年龄为66岁。3例为2009年国际妇产科联盟（FIGO）IA期，5例为IB期，2例为IIB期，3例为IVB期。10例患者接受了手术，8例接受了术后放疗。3例患者接受了辅助化疗。中位随访时间为16个月（2 - 276个月）。I期患者出现2例局部复发和3例远处转移（DM）。II期患者以及整个系列的61.5%也观察到了DM。接受放疗的患者中有50%仍存活且无复发。中位OS为16个月，I期为17个月，其余分期为9个月。
UUS预后不良与DM的高发生率相关。I期预后最佳。放疗似乎使患者受益，局部控制率达100%，长期生存率达50%。转移的高发生率表明需要更准确的初始评估。
