利用S1核酸酶与肽核酸（PNA）组合从人类基因组中剪切预定片段。
Clipping of predetermined fragments from the human genome by S1 nuclease-PNA combinations.
作者信息
Li Xia, Muneoka Satoshi, Shigi Narumi, Sumaoka Jun, Komiyama Makoto
机构信息
Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8577 Japan.
出版信息
Chem Commun (Camb). 2014 Aug 14;50(63):8674-6. doi: 10.1039/c4cc01420k. Epub 2014 Jun 24.
PMID:24958630
Abstract
By combining S1 nuclease with two strands of pseudo-complementary peptide nucleic acid (pcPNA), the whole human genome was selectively cut at targeted sites, and desired fragments were clipped from the genome.
摘要
通过将S1核酸酶与两条假互补肽核酸（pcPNA）链相结合，整个人类基因组在靶向位点被选择性切割，并且从基因组中剪下所需片段。
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