Liu Na, Xu Ziqian, Li Dandi, Zhang Qing, Wang Hong, Duan Zhao-Jun
Department of Viral Diarrhea, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Department of Viral Diarrhea, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Vaccine. 2014 Jul 31;32(35):4369-4375. doi: 10.1016/j.vaccine.2014.06.018. Epub 2014 Jun 20.
Rotavirus is the most common cause of severe diarrhea in children, and most associated deaths occur in developing countries. Two new internationally licensed vaccines are expected to be launched in the near future in China. We performed a systematic review and meta-analysis of rotavirus studies to update information on the burden of rotavirus disease in China.
Eligible studies published before 2011 were identified using PubMed/Medline, Embase, Cochrane Library, LILACS, WHOLIS, and two Chinese literature databases, CNKI, and WANFANG. Arc-sine transformations and the DerSimonian-Laird random-effects or fixed-effects models were used for meta-analysis.
A total of 211 studies were included in this review, of which 63 (29.9%) were inpatient studies, 26 (12.3%) were outpatient, 122 (57.8%) were combined. Community subjects were investigated in two combined studies. Rates of gastroenteritis caused by rotavirus in inpatients, outpatients, and community children were 42.6%, 32.5% and 9.3%, respectively. The most common G type was G3 (39.3%), followed by G1 (30.3%), G2 (7.2%), and G9 (3.3%). The most common P types were P[8] (50.2%), P[4] (18.2%), and P[6] (7.2%). The most prevalent G-P combinations were G3P[8] (32.1%), G1P[8] (23.0%), and G2P[4] (7.9%).
Rotavirus is an important cause of both severe and mild diarrheal disease in children <5 years of age in China; G3P[8] is the most prevalent strain. The introduction of an effective rotavirus vaccine to Chinese pediatric immunization programs is necessary.
轮状病毒是导致儿童严重腹泻的最常见病因，且大多数相关死亡发生在发展中国家。两种新的国际许可疫苗预计不久后将在中国上市。我们对轮状病毒研究进行了系统综述和荟萃分析，以更新中国轮状病毒疾病负担的相关信息。
使用PubMed/Medline、Embase、Cochrane图书馆、LILACS、WHOLIS以及两个中文文献数据库（中国知网和万方）检索2011年之前发表的符合条件的研究。采用反正弦变换以及DerSimonian-Laird随机效应或固定效应模型进行荟萃分析。
本综述共纳入211项研究，其中63项（29.9%）为住院患者研究，26项（12.3%）为门诊患者研究，122项（57.8%）为综合研究。两项综合研究对社区对象进行了调查。住院患者、门诊患者和社区儿童中由轮状病毒引起的胃肠炎发生率分别为42.6%、32.5%和9.3%。最常见的G型为G3（39.3%），其次是G1（30.3%）、G2（7.2%）和G9（3.3%）。最常见的P型为P[8]（50.2%）、P[4]（18.2%）和P[6]（7.2%）。最常见的G-P组合为G3P[8]（32.1%）、G1P[8]（23.0%）和G2P[4]（7.9%）。
轮状病毒是中国5岁以下儿童严重和轻度腹泻疾病的重要病因；G3P[8]是最常见的毒株。有必要将有效的轮状病毒疫苗引入中国儿童免疫规划。
